Invitrogen

APOE (R136S Mutant) Polyclonal Antibody

问题与答案

问题与答案

抗体检测数据 (1)

APOE (R136S Mutant) Antibody in Western Blot (WB)

APOE (R136S Mutant) Antibody in Western Blot (WB)

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APOE (R136S Mutant) Antibody (PA5-119519) in WB

Western blot analysis of APOE (R136S Mutant) in Non-transfected (-) and transfected (+) 293T whole cell extracts (30 µg). Sample was separated with 12% SDS-PAGE, incubated with polyclonal APOE (R136S Mutant) antibody (Product # PA5-119519) at a dilution of 1:1000, and followed by HRP-conjugated anti-rabbit IgG.

APOE (R136S Mutant) Antibody in Western Blot (WB)

Product Image Gallery

APOE (R136S Mutant) Antibody in Western Blot (WB) — Western blot analysis of APOE (R136S Mutant) in Non-transfected (-) and transfected (+) 293T whole cell extracts (30 µg). Sample was separated with 12% SDS-PAGE, incubated with polyclonal APOE (R136S Mutant) antibody (Product # PA5-119519) at a dilution of 1:1000, and followed by HRP-conjugated anti-rabbit IgG.

Immunogen image

APOE (R136S Mutant) Polyclonal Antibody

Immunogen Image APOE (R136S Mutant) Polyclonal Antibody

产品信息

PA5-119519

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

-

免疫细胞化学 (ICC/IF)

Assay-dependent

-

产品规格

种属反应

Human

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Carrier-protein conjugated synthetic peptide surrounding mutant R136S of human Apolipoprotein E. The exact sequence is proprietary.

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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1.15 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 1% BSA, 20% glycerol

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

产品详细信息

Store as concentrated solution. Centrifuge briefly prior to opening vial. For short-term storage (1-2 weeks), store at 4°C. For long-term storage, aliquot and store at -20°C or below. Avoid multiple freeze-thaw cycles.

靶标信息

The protein encoded by this gene is a major apoprotein of the chylomicron. It binds to a specific liver and peripheral cell receptor, and is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. This gene maps to chromosome 19 in a cluster with the related apolipoprotein C1 and C2 genes. Mutations in this gene result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jun 2016]

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: AD2; APO-E; ApoE4; Apolipoprotein E; apolipoprotein E3; LDLCQ5; LPG

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基因别名: AD2; APO-E; APOE; LDLCQ5; LPG

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UniProt ID: (Human) P02649

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Entrez Gene ID: (Human) 348

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beta-amyloid binding lipid transporter activity protein binding phospholipid binding heparin binding lipid binding cholesterol binding antioxidant activity cholesterol transporter activity identical protein binding protein homodimerization activity metal chelating activity tau protein binding low-density lipoprotein particle receptor binding phosphatidylcholine-sterol O-acyltransferase activator activity very-low-density lipoprotein particle receptor binding lipoprotein particle binding apolipoprotein

response to reactive oxygen species retinoid metabolic process negative regulation of endothelial cell proliferation response to dietary excess triglyceride metabolic process cholesterol catabolic process cellular calcium ion homeostasis receptor-mediated endocytosis cytoskeleton organization G-protein coupled receptor signaling pathway nitric oxide mediated signal transduction synaptic transmission, cholinergic cholesterol metabolic process regulation of gene expression negative regulation of platelet activation positive regulation of cholesterol esterification positive regulation of cholesterol efflux long-chain fatty acid transport protein import virion assembly triglyceride catabolic process cGMP-mediated signaling negative regulation of blood coagulation regulation of axon extension positive regulation of cGMP biosynthetic process neuron projection regeneration regulation of Cdc42 protein signal transduction positive regulation of low-density lipoprotein particle receptor catabolic process cholesterol efflux phospholipid efflux very-low-density lipoprotein particle remodeling low-density lipoprotein particle remodeling high-density lipoprotein particle remodeling high-density lipoprotein particle assembly chylomicron remnant clearance high-density lipoprotein particle clearance very-low-density lipoprotein particle clearance lipoprotein metabolic process lipoprotein biosynthetic process lipoprotein catabolic process vasodilation cholesterol homeostasis negative regulation of MAP kinase activity negative regulation of neuron apoptotic process negative regulation of blood vessel endothelial cell migration reverse cholesterol transport positive regulation by host of viral process negative regulation of cholesterol biosynthetic process positive regulation of lipid biosynthetic process intracellular transport regulation of neuronal synaptic plasticity artery morphogenesis negative regulation of inflammatory response positive regulation of nitric-oxide synthase activity positive regulation of membrane protein ectodomain proteolysis maintenance of location in cell fatty acid homeostasis positive regulation of dendritic spine development negative regulation of canonical Wnt signaling pathway AMPA glutamate receptor clustering NMDA glutamate receptor clustering cellular oxidant detoxification regulation of beta-amyloid clearance negative regulation of neuron death positive regulation of postsynaptic membrane organization negative regulation of presynaptic membrane organization negative regulation of beta-amyloid formation positive regulation of dendritic spine maintenance positive regulation of phospholipid efflux positive regulation of lipid transport across blood brain barrier