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Invitrogen
ARAP1 Polyclonal Antibody
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ARAP1 Antibody (PA5-87923) in WB
Western blot analysis of ARAP1 in extracts of various cell lines. Samples were incubated with ARAP1 Polyclonal antibody (Product # PA5-87923) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 10s.
产品信息
PA5-87923
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 834-1133 of human ARAP1 (NP_0011286621)
偶联物
形式
Liquid
浓度
2.87 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: SVDEEELRKQ REEITAIVKM RVAGTASGTQ HAGDFICTVY LEEKKAETEQ HIKVPASMTA EELTLEILDR RNVGIREKDY WTCFEVNERE EAERPLHFAE KVLPILHGLG TDSHLVVKKH QAMEAMLLYL ASRVGDTKHG MMKFREDRSL LGLGLPSGGF HDRYFILNSS CLRLYKEVRS HRPEKEWPIK SLKVYLGVKK KLRPPTCWGF TVVHETEKHE KQQWYLCCDT QMELREWFAT FLFVQHDGLV WPSEPSRVSR AVPEVRLGSV SLIPLRGSEN EMRRSVAAFT ADPLSLLRNV; Positive Samples: 293T, LO2, HeLa, Mouse liver, Rat liver; Cellular Location: Cell membrane, Cytoplasm, Golgi apparatus, Golgi stack membrane, Peripheral membrane protein
靶标信息
ARAP1 (angiotensin II type 1 receptor-associated protein) is an adaptor protein with ArfGAP and RhoGAP activities, containing five PH domains and ankyrin repeat. This adaptor seems to serve as a link between phosphoinositide- Arf-, and Rho-mediated cell signaling. ARAP1 supports the plasma membrane recycling of angiotensin II type 1 receptor (AT1) and is important also for cell-specific trafficking of pro-death receptor TRAIL-R1 (DR4) to the plasma membrane, thus promoting the TRAIL-induced apoptosis in certain cell types. ARAP1 also affects cell spreading.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: arap1; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1; centaurin, delta 2; Centaurin-delta-2; Cnt-d2
基因别名: 2410002L19Rik; Arap1; Centd2; Kiaa0782; mKIAA0782
UniProt ID: (Mouse) Q4LDD4
Entrez Gene ID: (Mouse) 69710, (Rat) 361617
