This antibody is predicted to react with bovine, canine, human and rat based on sequence homology.
The protein encoded by this gene is a GTPase-activating protein (GAP) that associates with the Golgi apparatus and regulates the early secretory pathway of proteins. The encoded protein promotes hydrolysis of ADP-ribosylation factor 1 (ARF1)-bound GTP, which is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles. Dissociation of the coat proteins is a prerequisite for the fusion of these vesicles with target compartments. The activity of this protein is sensitive to phospholipids. Multiple transcript variants encoding different isoforms have been found for this gene. This gene was originally known as ARFGAP1, but that is now the name of a related but different gene.
蛋白别名: ADP-ribosylation factor GTPase activating protein 1; ADP-ribosylation factor GTPase-activating protein 3; ARF GAP 3; ARF1GAP; FLJ45618; HRIHFB2281; MGC39924; OTTHUMP00000028526; RP1-47A17.3; RP11-261N11.1
基因别名: 0610009H19Rik; 1810004P07Rik; 1810035F16Rik; 9130416J18Rik; Arfgap1; Arfgap3
UniProt ID: (Mouse) Q9D8S3
Entrez Gene ID: (Mouse) 66251
分子生物学功能: GTPase-activating protein