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Proteintech
ARH Polyclonal Antibody
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产品信息
13213-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ARH Fusion Protein Ag4006 (1-308 aa encoded by BC029770)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MDALKSAGR ALIRSPSLAK QSWGGGGRHR KLPENWTDTR ETLLEGMLFS LKYLGMTLVE QPKGEELSAA AIKRIVATAK ASGKKLQKVT LKVSPRGIIL TDNLTNQLIE NVSIYRISYC TADKMHDKVF AYIAQSQHNQ SLECHAFLCT KRKMAQAVTL TVAQAFKVAF EFWQVSKEEK EKRDKASQEG GDVLGARQDC TPPLKSLVAT GNLLDLEETA KAPLSTVSAN TTNMDEVPRP QALSGSSVVW ELDDGLDEAF SRLAQSRTNP QVLDTGLTAQ DMHYAQCLSP VDWDKPDSSG TEQDDLFSF (1-308 aa encoded by BC029770 )
靶标信息
The protein encoded by this gene is a cytosolic protein which contains a phosphotyrosine binding (PTD) domain. The PTD domain has been found to interact with the cytoplasmic tail of the LDL receptor. Mutations in this gene lead to LDL receptor malfunction and cause the disorder autosomal recessive hypercholesterolaemia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Autosomal recessive hypercholesterolemia protein; DKFZp586D0624; LDL receptor adaptor protein; Low density lipoprotein receptor adapter protein 1; MGC34705; RP11-70P17.2
基因别名: ARH; ARH1; ARH2; FHCB1; FHCB2; LDLRAP1
UniProt ID: (Human) Q5SW96
Entrez Gene ID: (Human) 26119
beta-amyloid binding
phosphotyrosine binding
protein binding
phosphatidylinositol-4,5-bisphosphate binding
receptor signaling complex scaffold activity
clathrin binding
signaling adaptor activity
AP-2 adaptor complex binding
clathrin adaptor activity
low-density lipoprotein particle receptor binding
scaffold/adaptor protein
transport
receptor-mediated endocytosis
cholesterol metabolic process
positive regulation of signal transduction
receptor internalization
cholesterol homeostasis
amyloid precursor protein metabolic process
regulation of protein binding
positive regulation of receptor-mediated endocytosis
regulation of establishment of protein localization to plasma membrane
receptor-mediated endocytosis of low-density lipoprotein particle involved in cholesterol transport
positive regulation of cholesterol metabolic process
