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Invitrogen
ARHGAP22 Polyclonal Antibody
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ARHGAP22 Antibody (PA5-95800) in WB
Western blot analysis of ARHGAP22 in extracts of various cell lines. Samples were incubated with ARHGAP22 Polyclonal antibody (Product # PA5-95800) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 30s.
产品信息
PA5-95800
产品规格
种属反应
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 510-650 of human ARHGAP22 (NP_0012429531)
偶联物
形式
Liquid
浓度
0.6 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: NVPAPGLVPG IPSVASMAWS GASSSESSVG GSLSSCTACR ASDSSARSSL HTDWALEPSP LPSSSEDPKS LDLDHSMDEA GAGASNSEPS EPDSPTREHA RRSEALQGLV TELRAELCRQ RTEYERSVKR IEEGSADLRK R; Positive Samples: Mouse kidney, Mouse lung, Rat kidney, Rat lung; Cellular Location: Cytoplasm, Nucleus
靶标信息
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm, and contains one Rho-GAP domain and one PH domain. ARHGAP22 functions as a GTPase-activating protein for Rac 1 converting it to an inactive GDP-bound state and, through its interaction with ZNF161 (VEZF1), is thought to be useful in transcription regulation. Multiple isoforms of ARHGAP22 exist due to alternative splicing events.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: p68RacGAP; RHG22; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22
基因别名: Arhgap22; B230341L19Rik; p68RacGAP; RHOGAP2
UniProt ID: (Mouse) Q8BL80
Entrez Gene ID: (Mouse) 239027, (Rat) 306279
