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产品信息
PA5-50114
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthesized peptide derived from N-terminal of human ARHGEF11. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 50% glycerol |
内含物 |
0.02% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2635567 |
产品详细信息
The antibody detects endogenous levels of total ARHGEF11 protein.
靶标信息
ARHGEF11 is a 1527 amino acid protein with tandem dbl homology and pleckstrin homology domains, PDZ domain, two proline rich sequences and a regulatory G protein-signaling (RGS) sequence. It acts as guanine nucleotide exchange factor (GEF) for RhoA GTPase, but not for RAC1 or CDC42 and acts as GTPase-activating protein (GAP) for GNA12 and GNA13. It forms a complex with G proteins and stimulates neurite through retraction Rho-dependent signals. ARHGEF11 increases glutamate transport 4-fold. It interacts with EAAT4 and modulates its uptake activity and perisynaptic distribution at glutamatergic synapses. It is known to induce the reorganization of the actin cytoskeleton and its overexpression induces the formation of membrane ruffling and filopodia. It is ubiquitously expressed, in brain, lung, liver, kidney and skeletal muscle.
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生物信息学
蛋白别名: glutamate transporter EAAT4-associated protein 48; PDZ-RhoGEF; Rho guanine exchange factor (GEF) 11; Rho guanine nucleotide exchange factor (GEF) 11; Rho guanine nucleotide exchange factor 11; RhoA-specific guanine nucleotide exchange factor; RhoGEF glutamate transport modulator; RP11-356J7.2
基因别名: ARHGEF11; GTRAP48; KIAA0380; PDZ-RHOGEF
UniProt ID: (Human) O15085
Entrez Gene ID: (Human) 9826
分子生物学功能:
guanyl-nucleotide exchange factor
cytokinesis
regulation of cell growth
movement of cell or subcellular component
striated muscle contraction
G-protein coupled receptor signaling pathway
Rho protein signal transduction
establishment of cell polarity
actin cytoskeleton organization
regulation of Rho protein signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
positive regulation of transcription, DNA-templated
regulation of small GTPase mediated signal transduction
