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Invitrogen
ARHGEF17 Polyclonal Antibody
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ARHGEF17 Antibody (PA5-103351) in IHC (P)
Immunohistochemistry analysis of ARHGEF17 in mouse heart tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with ARHGEF17 polyclonal antibody (Product # PA5-103351) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
产品信息
PA5-103351
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A synthesized peptide derived from human ARHGEF17(Accession Q96PE2), corresponding to amino acid residues T1679-L1729.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.4, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Antibody detects endogenous levels of total ARHGEF17.
靶标信息
Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 164 kDa Rho-specific guanine-nucleotide exchange factor; p164-RhoGEF; Rho guanine nucleotide exchange factor (GEF) 17; Rho guanine nucleotide exchange factor 17; Rho-specific guanine-nucleotide exchange factor 164 kDa; Tumor endothelial marker 4
基因别名: 8030463K16; AI428794; ARHGEF17; AW558066; BC035332; KIAA0337; mKIAA0337; p164-RhoGEF; P164RHOGEF; TEM4
UniProt ID: (Human) Q96PE2, (Mouse) Q80U35
Entrez Gene ID: (Human) 9828, (Mouse) 207212
