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OriGene
ARHGEF2 Monoclonal Antibody (OTI5F2), TrueMAB™
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ARHGEF2 Antibody (CF809320) in WB
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ARHGEF2 (RC204546, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-ARHG. Positive lysates LY417793 (100 µg) and LC417793 (20 µg) can be purchased separately from OriGene.
产品信息
CF809320
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Mouse
/ IgG1
分类
Monoclonal
类型
Antibody
克隆号
OTI5F2
抗原
Full length human recombinant protein of human ARHGEF2 produced in HEK293T cell.
偶联物
形式
Lyophilized
浓度
1 mg/mL
纯化类型
Affinity chromatography
保存液
PBS, pH 7.3, with 8% trehalose
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
For reconstitution, we recommend adding 100 µL distilled water to a final antibody concentration of about 1 mg/mL. To use this carrier-free antibody for conjugation experiments, we strongly recommend performing another round of desalting. (Zeba Spin Desalting Columns, 7KMWCO, 0.5 mL, Product # 89882)
靶标信息
GEF-H1 activates Rho GTPases by promoting the exchange of GDP and GTP. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. GEF-H1 may be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Alternatively spliced transcript variants encoding different isoforms have been identified.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: DKFZp547L106; DKFZp547P1516; FLJ45440; GEF-H1; Guanine nucleotide exchange factor H1; LBC'S first cousin; Lymphoid blast crisis-like 1; Microtubule-regulated Rho-GEF; Oncogene LFC; OTTHUMP00000018855; Proliferating cell nucleolar antigen p40; Rho guanine nucleotide exchange factor 2; Rho/Rac guanine nucleotide exchange factor (GEF) 2; Rhobin
基因别名: AA408978; ARHGEF2; GEF; GEF-H1; GEFH1; KIAA0651; Lbcl1; Lfc; LFP40; mKIAA0651; P40
UniProt ID: (Human) Q92974, (Mouse) Q60875, (Rat) Q5FVC2
Entrez Gene ID: (Human) 9181, (Mouse) 16800, (Rat) 310635
establishment of mitotic spindle orientation
cell morphogenesis
intracellular protein transport
actin filament organization
negative regulation of microtubule depolymerization
mitotic nuclear division
positive regulation of interleukin-6 production
positive regulation of tumor necrosis factor production
regulation of Rho protein signal transduction
intracellular signal transduction
regulation of cell proliferation
positive regulation of apoptotic process
positive regulation of GTPase activity
innate immune response
positive regulation of transcription from RNA polymerase II promoter
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of neurogenesis
regulation of small GTPase mediated signal transduction
positive regulation of NF-kappaB transcription factor activity
cell division
negative regulation of necroptotic process
cellular response to muramyl dipeptide
cellular response to tumor necrosis factor
cellular hyperosmotic response
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress
immune system process
cell cycle
