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Proteintech
ARIH1 Polyclonal Antibody
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产品信息
14949-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ARIH1 fusion protein Ag6760
偶联物
形式
Liquid
浓度
0.6 mg/mL
规格
90 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: MQCWSEYLTT KIMEEGMGQT ISCPAHGCDI LVDDNTVMRL ITDSKVKLKY QHLITNSFVE CNRLLKWCPA PDCHHVVKVQ YPDAKPVRCK CGRQFCFNCG ENWHDPVKCK WLKKWIKKCD DDSETSNWIA ANTKECPKCH VTIEKDGGCN HMVCRNQNCK AEFCWVCLGP WEPHGSAWYN CNRYNEDDAK AARDAQERSR AALQRYLFYC NRYMNHMQSL RFEHKLYAQV KQKMEEMQQH NMSWIEVQFL KKAVDVLCQC RATLMYTYVF AFYLKKNNQS IIFENNQADL ENATEVLSG
靶标信息
E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:15236971, PubMed:21532592, PubMed:24076655, PubMed:27565346, PubMed:23707686). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-RING ubiquitin ligase (CRL) complexes and initiating ubiquitination of CRL substrates: associates with CRL complexes and specifically mediates addition of the first ubiquitin on CRLs targets (PubMed:27565346). The initial ubiquitin is then elongated by CDC34/UBE2R1 and UBE2R2 (PubMed:27565346). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated cullin-RING ubiquitin ligase complexes (PubMed:24076655, PubMed:27565346). Plays a role in protein translation in response to DNA damage by mediating ubiquitination of EIF4E2, the consequences of EIF4E2 ubiquitination are however unclear (PubMed:25624349). According to a report, EIF4E2 ubiquitination leads to promote EIF4E2 cap-binding and protein translation arrest (PubMed:25624349). According to another report EIF4E2 ubiquitination leads to its subsequent degradation (PubMed:14623119). Acts as the ligase involved in ISGylation of EIF4E2 (PubMed:17289916). In vitro, controls the degradation of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex member SUN2 and may therefore have a role in the formation and localization of the LINC complex, and as a consequence, nuclear subcellular localization and nuclear morphology (PubMed:29689197). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ARI-1; ARI; E3; ariadne 1; ariadne homolog, ubiquitin-conjugating enzyme E2 binding protein, 1; ariadne, Drosophila, homolog of; DKFZp686O13120; E3 ubiquitin-protein ligase ARIH1; FLJ20329; FLJ93118; H7-AP2; HHARI; Monocyte protein 6; MOP-6; Protein ariadne-1 homolog; UbcH7-binding protein; UbcM4-interacting protein; UbcM4-interacting protein 77; Ubiquitin-conjugating enzyme E2-binding protein 1; unnamed protein product
基因别名: ARI; Ari1; ARIH1; AU021774; HARI; HHARI; HUSSY-27; MOP6; UBCH7BP; Uip77
UniProt ID: (Human) Q9Y4X5, (Mouse) Q9Z1K5
Entrez Gene ID: (Human) 25820, (Mouse) 23806
ubiquitin-protein transferase activity
protein binding
zinc ion binding
transferase activity
ubiquitin-like protein transferase activity
ubiquitin conjugating enzyme binding
ubiquitin protein ligase binding
metal ion binding
ubiquitin protein ligase activity
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity
ligase activity
ribosomal S6-glutamic acid ligase activity
coenzyme F420-0 gamma-glutamyl ligase activity
coenzyme F420-2 alpha-glutamyl ligase activity
protein-glycine ligase activity
protein-glycine ligase activity, initiating
protein-glycine ligase activity, elongating
tubulin-glycine ligase activity
protein-glutamic acid ligase activity
tubulin-glutamic acid ligase activity
ubiquitin-protein ligase
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