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Proteintech
ARNT2 Polyclonal Antibody
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产品信息
12810-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ARNT2 Fusion Protein Ag3536 (363-716 aa encoded by BC036099)
偶联物
形式
Liquid
浓度
0.23 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human ARNT2.
Immunogen sequence: QDLLGKDIL EFCHPEDQSH LRESFQQVVK LKGQVLSVMY RFRTKNREWM LIRTSSFTFQ NPYSDEIEYI ICTNTNVKQL QQQQAELEVH QRDGLSSYDL SQVPVPNLPA GVHEAGKSVE KADAIFSQER DPRFAEMFAG ISASEKKMMS SASAAGTQQI YSQGSPFPSG HSGKAFSSSV VHVPGVNDIQ SSSSTGQNMS QISRQLNQSQ VAWTGSRPPF PGQQIPSQSS KTQSSPFGIG TSHTYPADPS SYSPLSSPAT SSPSGNAYSS LANRTPGFAE SGQSSGQFQG RPSEVWSQWQ SQHHGQQSGE QHSHQQPGQT EVFQDMLPMP GDPGNEWWSP HSRQHFRQPI SYARM (363-716 aa encoded by BC036099)
靶标信息
AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: ARNT 2; ARNT protein 2; Aryl hydrocarbon receptor nuclear translocator 2; aryl-hydrocarbon receptor nuclear translocator 2; bHLHe1; Class E basic helix-loop-helix protein 1
基因别名: ARNT2; BHLHE1; Hif-2b; KIAA0307; mKIAA0307; WEDAS
UniProt ID: (Human) Q9HBZ2, (Mouse) Q61324, (Rat) Q78E60
Entrez Gene ID: (Human) 9915, (Mouse) 11864, (Rat) 25243
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
aryl hydrocarbon receptor binding
protein heterodimerization activity
DNA binding
signal transducer activity
protein dimerization activity
basic helix-loop-helix transcription factor
response to hypoxia
in utero embryonic development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
central nervous system development
brain development
positive regulation of cell proliferation
response to estradiol
negative regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
signal transduction
response to xenobiotic stimulus
response to toxic substance
