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Invitrogen
ARNT2 Polyclonal Antibody
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产品信息
PA5-30338
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant protein encompassing a sequence within the center region of human ARNT2. The exact sequence is proprietary.
偶联物
形式
Liquid
浓度
0.47 mg/mL
纯化类型
Antigen affinity chromatography
保存液
0.1M tris glycine, pH 7, with 20% glycerol
内含物
0.01% thimerosal
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Recommended positive controls: Mouse brain.
Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (88%), Xenopus laevis (91%), Sheep (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
靶标信息
AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ARNT 2; ARNT protein 2; Aryl hydrocarbon receptor nuclear translocator 2; aryl-hydrocarbon receptor nuclear translocator 2; bHLHe1; Class E basic helix-loop-helix protein 1
基因别名: ARNT2; BHLHE1; Hif-2b; KIAA0307; mKIAA0307; WEDAS
UniProt ID: (Human) Q9HBZ2, (Mouse) Q61324
Entrez Gene ID: (Human) 9915, (Mouse) 11864
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
aryl hydrocarbon receptor binding
protein heterodimerization activity
DNA binding
signal transducer activity
protein dimerization activity
basic helix-loop-helix transcription factor
response to hypoxia
in utero embryonic development
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
central nervous system development
brain development
positive regulation of cell proliferation
response to estradiol
negative regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
signal transduction
response to xenobiotic stimulus
response to toxic substance
