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Abnova
ARRB2 Monoclonal Antibody (3G1)
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Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
H00000409-M01
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
3G1
抗原
ARRB2 (AAH07427, 300 a.a. approximately 409 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
no preservative
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
产品详细信息
Product may be used with Western Blot (Transfected lysate).
Immunogen sequence: NLASSTIVKE GANKEVLGIL VSYRVKVKLV VSRGGDVSVE LPFVLMHPKP HDHIPLPRPQ SAAPETDVPV DTNLIEFDTN YATDDDIVFE DFARLRLKGM KDDDYDDQLC
靶标信息
Beta-arrestin-2, or ARRB2, is an adaptor protein belonging to the arrestin family with an N- arrestin domain and a C- arrestin domain. ARRB2 is a regulatory protein involved in heterotrimeric G protein-coupled receptor desensitization and is known to regulate beta2-adrenergic receptor (beta2AR) function by enhancing beta2AR mediated nuclear translocation of ERK. ARRB2 binds to phosphorylated beta2ARs, thereby causing a significant impairment of their capacity to activate G(S) proteins. Along with AIP4, ARRB2 acts as an endosomal sorting molecule that mediates CXCR4 entry into a degradative pathway. It may also be involved in hormone-specific desensitization of TSH receptors. ARRB2 is a Ca2+ binding protein of the retinal outer segments and binds to P-rhodopsin and is also involved in synaptic transmission in photoreceptor cells. It is widely expressed in most of the tissues, especially neuronal tissues and spleen.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: activated GPCR interaction protein; ARRB2; arrestin 3; non-visual arrestin-3; unnamed protein product
基因别名: ARB2; ARR2; BARR2
UniProt ID: (Human) P32121
Entrez Gene ID: (Human) 409
desensitization of G-protein coupled receptor protein signaling pathway
G-protein coupled receptor internalization
positive regulation of receptor internalization
transcription from RNA polymerase II promoter
signal transduction
transforming growth factor beta receptor signaling pathway
adult walking behavior
positive regulation of cardiac muscle hypertrophy
positive regulation of gene expression
protein ubiquitination
sensory perception of pain
negative regulation of protein ubiquitination
receptor internalization
positive regulation of synaptic transmission, dopaminergic
negative regulation of interleukin-1 beta production
negative regulation of interleukin-12 production
negative regulation of interleukin-6 production
negative regulation of tumor necrosis factor production
negative regulation of toll-like receptor signaling pathway
negative regulation of I-kappaB kinase/NF-kappaB signaling
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of smoothened signaling pathway
negative regulation of natural killer cell mediated cytotoxicity
modulation of synaptic transmission
positive regulation of protein kinase B signaling
negative regulation of protein kinase B signaling
excitatory postsynaptic potential
cell chemotaxis
chemokine-mediated signaling pathway
positive regulation of ERK1 and ERK2 cascade
protein localization to nonmotile primary cilium
postsynaptic signal transduction
beta-arrestin-dependent dopamine receptor signaling pathway
positive regulation of intracellular signal transduction
positive regulation of cardiac muscle cell differentiation
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