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Proteintech
ARRDC1 Polyclonal Antibody
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产品信息
21030-1-AP
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ARRDC1 fusion protein Ag15341
偶联物
形式
Liquid
浓度
0.35 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice
产品详细信息
Immunogen sequence: HSFPFQFLLP ATAPTSFEGP FGKIVHQVRA AIHTPRFSKD HKCSLVFYIL SPLNLNSIPD IEQPNVASAT KKFSYKLVKT GSVVLTASTD LRGYVVGQAL QLHADVENQS GKDTSPVVAS LLQKVSYKAK RWIHDVRTIA EVEGAGVKAW RRAQWHEQIL VPALPQSALP GCSLIHIDYY LQVSLKAPEA TVTLPVFIGN IAVNHAPVSP RPGLGLPPGA PPLVVPSAPP QEEAEAEAAA GGPHFLDPVF LSTKSHSQRQ PLLATLSSVP GAPEPCPQDG SPASHPLHPP LCISTGATVP YFAEGSGGPV PTTSTLILPP EYSSWGYPYE APPSYEQSCG GVEPSLTPES
靶标信息
Functions as an adapter recruiting ubiquitin-protein ligases to their specific substrates (PubMed:23886940, PubMed:27462458). Through an ubiquitination-dependent mechanism plays for instance a role in the incorporation of SLC11A2 into extracellular vesicles (PubMed:27462458). More generally, plays a role in the extracellular transport of proteins between cells through the release in the extracellular space of microvesicles (PubMed:22315426). By participating in the ITCH-mediated ubiquitination and subsequent degradation of NOTCH1, negatively regulates the NOTCH signaling pathway (PubMed:23886940). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Alpha-arrestin 1; Arrestin domain-containing protein 1
基因别名: ARRDC1
UniProt ID: (Human) Q8N5I2
Entrez Gene ID: (Human) 92714
