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Proteintech
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Immunogen sequence: RRKATDAKD PSVIEEPNGE PNGVTVTAEA VSQASSHPEN SEEEECMGAA AAVGPAMCGV ELDSLISQVK DLLPDLGEGF ILACLEYYHY DPEQVINNIL EERLAPTLSQ LDRNLDREMK PDPTPLLTSR HNVFQNDEFD VFSRDSVDLS RVHKGKSTRK EENTRSLLND KRAVAAQRQR YEQYSVVVEE VPLQPGESLP YHSVYYEDEY DDTYDGNQVG ANDADSDDEL ISRRPFTIPQ VLRTKVPREG QEEDDDDEED DADEEAPKPD HFVQDPAVLR EKAEARRMAF LAKKGYRHDS STAVAGSPRG HGQSRETTQE RRKKEANKAT RANHNRRTMA DRKRSKGMIP S
Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). [UniProt]
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activating signal cointegrator 1 complex subunit 2; ASC-1 complex subunit P100; Trip4 complex subunit p100
基因别名: 1700011I11Rik; 2610034L15Rik; AI482016; ASC1P100; ASCC2; AW046480; p100; RGD1561422; RQT3
UniProt ID: (Human) Q9H1I8, (Mouse) Q91WR3
Entrez Gene ID: (Human) 84164, (Mouse) 75452, (Rat) 498402