Invitrogen

ASCC2 Polyclonal Antibody

产品信息

PA5-50623

应用	建议稀释比	已发表文章
免疫印迹 (WB)	1:200-1:1,000	-

产品规格
种属反应	Human, Mouse
宿主/亚型	Rabbit / IgG
分类	Polyclonal
类型	Antibody
抗原	Synthetic peptide corresponding to a region derived from internal residues of human activating signal cointegrator 1 complex subunit 2
偶联物	Unconjugated
形式	Liquid
浓度	2.2 mg/mL
纯化类型	Antigen affinity chromatography
保存液	PBS, pH 7.4, with 40% glycerol
内含物	0.05% sodium azide
保存条件	-20°C
RRID	AB_2636076

产品详细信息

The antibody detects endogenous levels of total ASCC2 protein.

靶标信息

Plays a role in DNA damage repair as component of the ASCC complex. Recruits ASCC3 and ALKBH3 to sites of DNA damage by binding to polyubiquitinated proteins that have 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Part of the ASC-1 complex that enhances NF-kappa-B, SRF and AP1 transactivation (PubMed:12077347). [UniProt]

仅用于科研。不用于诊断过程。未经明确授权不得转售。