Search
Proteintech
ATF2 Polyclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
{{$ctrl.translations['antibody.pdp.skuNotes.additionalInformation']}}:
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
11908-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
ATF2 Fusion Protein Ag2581 (1-209 aa encoded by BC026175)
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.35 mg/mL
规格
52.5 µg
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody can recognize all the isoforms of human ATF2. The molecular weight detected is larger than the theoretical value, which may be related to protein modification. About 65-68 kDa band detected in the articles.
Immunogen sequence: MKFKLHVNS ARQYKDLWNM SDDKPFLCTA PGCGQRFTNE DHLAVHKHKH EMTLKFGPAR NDSVIVADQT PTPTRFLKNC EEVGLFNELA SPFENEFKKA SEDDIKKMPL DLSPLATPII RSKIEEPSVV ETTHQDSPLP HPESTTSDEK EVPLAQTAQP TSAIVRPASL QVPNVLLTSS DSSVIIQQAV PSPTSSTVIT QAPSSNRPIV (1-209 aa encoded by BC026175)
靶标信息
The transcription factor ATF-2 (also called CRE-BP1) binds to both AP-1 and CRE DNA response elements and is a member of the ATF/CREB family of leucine zipper proteins. ATF-2 interacts with a variety of viral oncoproteins and cellular tumor suppressors and is a target of the SAPK/JNK and p38 MAP kinase signaling pathways. Various forms of cellular stress, including genotoxic agents, inflammatory cytokines and UV irradiation, stimulate the transcriptional activity of ATF-2. Cellular stress activates ATF-2 by phosphorylation of Thr69 and Thr71. Both SAPK and p38 MAPK have been shown to phosphorylate ATF-2 at these sites in vitro and in cells transfected with ATF-2.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Activating 2; ATF2; bZIP transcription factor; cAMP response element-binding protein CRE-BP1; cAMP responsive element binding protein 2, formerly; cAMP-dependent transcription factor ATF-2; cyclic AMP response element-binding protein (HB16); cyclic AMP-responsive element-binding protein 2; histone acetyltransferase ATF2; MGC111558; mXBP protein; OTTHUMP00000205345; OTTHUMP00000205347; OTTHUMP00000205348; OTTHUMP00000205350; OTTHUMP00000205352; OTTHUMP00000205353; OTTHUMP00000205354; RATF2; unnamed protein product
基因别名: Atf-2; CRE-BP; CRE-BP1; CREB-2; CREB2; D130078H02Rik; HB16; mXBP; Tg(Gzma-Klra1)7Wum; TREB7
UniProt ID: (Human) P15336, (Mouse) P16951, (Rat) Q00969
Entrez Gene ID: (Human) 1386, (Mouse) 11909, (Rat) 81647
RNA polymerase II regulatory region sequence-specific DNA binding
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II transcription factor activity, sequence-specific DNA binding
core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
chromatin binding
transcription factor activity, sequence-specific DNA binding
histone acetyltransferase activity
protein binding
cAMP response element binding protein binding
H4 histone acetyltransferase activity
protein kinase binding
cAMP response element binding
identical protein binding
protein homodimerization activity
leucine zipper domain binding
sequence-specific DNA binding
histone H2B acetyltransferase activity
protein heterodimerization activity
RNA polymerase II sequence-specific DNA binding transcription factor binding
sequence-specific double-stranded DNA binding
promoter-specific chromatin binding
macromolecular complex binding
negative regulation of transcription from RNA polymerase II promoter
MAPK cascade
cellular glucose homeostasis
in utero embryonic development
NK T cell differentiation
liver development
positive regulation of protein phosphorylation
hematopoietic progenitor cell differentiation
outflow tract morphogenesis
brainstem development
growth plate cartilage chondrocyte differentiation
growth plate cartilage chondrocyte proliferation
regulation of transcription, DNA-templated
regulation of transcription from RNA polymerase II promoter
protein import into nucleus
lipid metabolic process
apoptotic process
response to osmotic stress
cellular response to DNA damage stimulus
vacuole organization
JNK cascade
heart development
gene expression
positive regulation of gene expression
negative regulation of angiogenesis
abducens nucleus development
hypoglossal nucleus development
facial nucleus development
BMP signaling pathway
intra-S DNA damage checkpoint
positive regulation of transforming growth factor beta2 production
cellular response to oxidative stress
p38MAPK cascade
mRNA transcription from RNA polymerase II promoter
positive regulation of neuron apoptotic process
fat cell differentiation
positive regulation of gene expression, epigenetic
positive regulation of transcription from RNA polymerase II promoter
negative regulation of epithelial cell proliferation
white fat cell differentiation
neurofilament cytoskeleton organization
detection of cell density
adipose tissue development
cellular response to anisomycin
motor neuron apoptotic process
amelogenesis
hepatocyte apoptotic process
cellular response to virus
positive regulation of cardiac muscle myoblast proliferation
positive regulation of mitochondrial membrane permeability involved in apoptotic process
intrinsic apoptotic signaling pathway in response to hypoxia
cellular response to leucine starvation
peptidyl-threonine phosphorylation
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
