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This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor 4b1 (tax-responsive enhancer element B67); ATF 4; ATF4 protein; cAMP-dependent transcription factor ATF-4; CREB 2; Cyclic AMP-dependent transcription factor ATF-4; OTTHUMP00000199130; tax-re
基因别名: atf4; atf4a; atf4b1; wu:fj01c08; wu:fk30b04; zgc:85951
UniProt ID: (Zebrafish) Q6NW59
Entrez Gene ID: (Zebrafish) 406514