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Invitrogen
ATG5 Monoclonal Antibody (1358CT289.125.123)
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ATG5 Antibody (MA5-37654) in WB
Western Blot analysis of ATG5 using the ATG5 Monoclonal Antibody (Product # MA5-37654) at a dilution of 1:1,000 in Hela, U-87 MG, mouse NIH/3T3, rat C6 cells (from left to right) (35 µg per lane). A goat anti-mouse IgG H&L(HRP) at 1:3000 dilution was used as the secondary antibody.
产品信息
MA5-37654
产品规格
宿主/亚型
Mouse
/ IgG1, kappa
分类
Monoclonal
类型
Antibody
克隆号
1358CT289.125.123
抗原
recombination protein from the human region of human ATG5
偶联物
形式
Liquid
浓度
0.47 mg/mL
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
靶标信息
ATG5 (Autophagy Related 5) is an important element for autophagy and may play an important role in the apoptotic process. ATG5 is also involved in other cellular processes that include mitochondrial quality control after oxidative damage, negative regulation of the innate anti-viral immune response, lymphocyte development and proliferation, MHC II antigen presentation, and adipocyte differentiation. Following conjugation to ATG12, the conjugate participates in the formation of autophagosome. ATG5 contributes to autophagic cell death by interacting with Fas-associated protein with death domain (FADD). The ATG5-ATG12 conjugate forms a cup-shaped isolation membrane that then detaches from the membrane immediately before or after autophagosome formation is completed. APG5 may play a role in the apoptotic process, possibly within the modified cytoskeleton. Further, APG5 expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. The APG5-APG12 conjugate also associates with innate immune response proteins such as RIG-I and VISA (also known as IPS-1), inhibiting type I interferon production and permitting viral replication in host cells. Diseases associated with ATG5 dysfunction include spinocerebellar ataxia.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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