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Invitrogen
ATP11C Polyclonal Antibody
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ATP11C Antibody (PA5-109426) in WB
Western blot analysis of ATP11C in extracts of various cell lines. Samples were incubated with ATP11C Polyclonal antibody (Product # PA5-109426) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 5s.
产品信息
PA5-109426
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 430-650 of human ATP11C (NP_775965.2).
偶联物
形式
Liquid
浓度
2.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: DGHKYKGVTQ EVDGLSQTDG TLTYFDKVDK NREELFLRAL CLCHTVEIKT NDAVDGATES AELTYISSSP DEIALVKGAK RYGFTFLGNR NGYMRVENQR KEIEEYELLH TLNFDAVRRR MSVIVKTQEG DILLFCKGAD SAVFPRVQNH EIELTKVHVE RNAMDGYRTL CVAFKEIAPD DYERINRQLI EAKMALQDRE EKMEKVFDDI ETNMNLIGAT A
靶标信息
The ATP11C gene encodes a protein that belongs to the P4-ATPase family, specifically functioning as a phospholipid-transporting ATPase. ATP11C plays a critical role in the maintenance of phospholipid asymmetry across the cell membrane by transporting aminophospholipids from the outer leaflet to the inner leaflet of the plasma membrane. This activity is essential for various biological processes, including cell membrane integrity, cell signaling, and apoptosis. ATP11C is particularly important in hematopoiesis, influencing the development of B cells and red blood cells. Mutations or dysregulation in ATP11C can lead to disruptions in cell membrane dynamics and are associated with immunological disorders and anemia. Research on ATP11C continues to focus on its role in phospholipid transport and its implications for cellular function and disease, particularly in the context of blood-related disorders.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: Atpase 11c, p type; ATPase class VI type 11C; ATPase IQ; ATPase, class VI, type 11C; P4-ATPase flippase complex alpha subunit ATP11C; Phospholipid-transporting ATPase 11C; Phospholipid-transporting ATPase IG; probable phospholipid-transporting ATPase 11C; probable phospholipid-transporting ATPase IG
基因别名: A330005H02Rik; AI315324; ATP11C; ATPIG; ATPIQ; Ig
UniProt ID: (Human) Q8NB49, (Mouse) Q9QZW0
Entrez Gene ID: (Human) 286410, (Mouse) 320940
