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产品信息
PA1-16975
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide corresponding to residues 200-300 of human ATP13A2.
偶联物
Unconjugated
形式
Liquid
浓度
0.75 mg/mL
纯化类型
Antigen affinity chromatography
保存液
tris glycine with 150mM NaCl
内含物
0.05% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2063283
产品详细信息
Suggested positive control: human and mouse brain membrane prep lysate.
靶标信息
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AT132 antibody; ATPase type 13A2; HSA9947 antibody; Polyamine-transporting ATPase 13A2; probable cation-transporting ATPase 13A2; putative ATPase; RP1-37C10.4
基因别名: 1110012E06Rik; AA589443; ATP13A2; CLN12; HSA9947; KRPPD; PARK9
UniProt ID: (Human) Q9NQ11, (Mouse) Q9CTG6
Entrez Gene ID: (Human) 23400, (Mouse) 74772
cellular calcium ion homeostasis
cellular iron ion homeostasis
cellular zinc ion homeostasis
regulation of mitochondrion organization
regulation of macroautophagy
regulation of autophagosome size
cellular cation homeostasis
regulation of intracellular protein transport
ion transmembrane transport
cellular response to oxidative stress
protein autophosphorylation
positive regulation of protein secretion
regulation of endopeptidase activity
zinc ion homeostasis
cellular response to manganese ion
cellular response to zinc ion
cation transmembrane transport
negative regulation of neuron death
regulation of mitophagy
positive regulation of exosomal secretion
regulation of chaperone-mediated autophagy
autophagosome organization
polyamine import
regulation of lysosomal protein catabolic process
negative regulation of lysosomal protein catabolic process
peptidyl-aspartic acid autophosphorylation
cation transport
