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PA1-18321 detects ATPase from rat samples.
PA1-18321 has been successfully used in immunohistochemistry procedures.
The PA1-18321 immunogen is a synthetic peptide corresponding to residues C-E(147) L H R Q E E A K Q V L R Y Y(161) of mouse ATP13A2, conjugated to KLH.
Reconstitute with 100 µL of distilled water.
Neurodegenerative disorders such as Parkinson and Alzheimer disease cause motor and cognitive dysfunction and belong to a heterogeneous group of common and disabling disorders. ATP13A2, otherwise known as PARK9, is a neuronal P-type ATPase gene underlying an autosomal recessive form of early-onset parkinsonism with pyramidal degeneration and dementia. ATP13A2 protein is located in the membrane of these lysosomes and is formed most strongly in the brain, especially in the substantia nigra, a brain region which is known to play a central role in Parkinson's disease.
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