Proteintech

ATP1A1/2 Monoclonal Antibody (3D8G1)

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ATP1A1/2 Monoclonal Antibody (3D8G1)

产品信息

68505-1-IG

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:5,000-1:50,000
-

免疫细胞化学 (ICC/IF)

1:500-1:2,000
-

酶联免疫吸附实验 (ELISA)

Assay-dependent
-
产品规格

种属反应

Human, Mouse, Pig, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

3D8G1

抗原

ATP1A1/2 fusion protein Ag10489
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.5 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice

产品详细信息

Immunogen sequence: KRMARKNCLV KNLEAVETLG STSTICSDKT GTLTQNRMTV AHMWFDNQIH EADTTEDQSG ATFDKRSPTW TALSRIAGLC NRAVFKAGQE NISVSKRDTA GDASESALLK CIELSCGSVR KMRDRNPKVA EIPFNSTNKY QLSIHEREDS PQSHVLVMKG APERILDRCS TILVQGKEIP LDKEMQDAFQ NAYMELGGLG ERVLGFCQLN LPSGKFPRGF KFDTDELNFP TEKLCFVGLM SMIDPPRAAV PDAVGKCRSA GIKVIMVTGD HPITAKAIAK GVGIISEGNE TVEDIAARLN IPMSQVNPRE AKACVVHGSD LKDMTSEQLD EILKNHTEIV FARTSPQQKL IIVE

靶标信息

ATP1A1/2 is the catalytic component of the active enzyme Na+/K+-ATPase, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. The Na+/K+-ATPase is composed of a larger catalytic alpha-subunit (~110 kDa) and a small beta-subunit (~55 kDa). The alpha subunit has four isoforms identified to date: alpha 1, alpha 2, alpha 3 and alpha 4.The alpha 1 isoform is expressed ubiquitously but the alpha 2 isoform is present largely in the skeletal muscle, heart and vascular smooth muscle. The alpha 3 isoform is found almost exclusively in neurons and ovaries. The alpha 4 isoform is expressed in sperm.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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生物信息学

蛋白别名: (Na+, K+)-ATPase alpha-subunit; ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+K+ transporting, alpha 1; ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-1 subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+ ,K+ -ATPase alpha subunit; Na+ /K+ ATPase alpha 1 subunit; Na+, K+-ATPase beta-subunit precursor; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Na+/K+ transporting alpha 1 polypeptide; Na+/K+ transporting alpha 2 polypeptide; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha 2 subunit; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; Sodium pump subunit alpha-1; Sodium pump subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium-ATPase, alpha 1 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; Sodium/potassium-transporting ATPase subunit alpha-1; Sodium/potassium-transporting ATPase subunit alpha-2; unnamed protein product

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基因别名: ATP1A1; ATP1A2; Atpa-1; Atpa-3; AW060654; BC010319; FHM2; KIAA0778; MHP2; mKIAA0778; Nkaa1b; RATATPA2

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UniProt ID: (Human) P05023, (Pig) P05024, (Human) P50993, (Pig) D2WKD8, (Rat) P06685, (Mouse) Q8VDN2, (Rat) P06686, (Mouse) Q6PIE5

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Entrez Gene ID: (Human) 476, (Pig) 397481, (Human) 477, (Pig) 396828, (Rat) 24211, (Mouse) 11928, (Rat) 24212, (Mouse) 98660

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功能
sodium:potassium-exchanging ATPase activity protein binding ATP binding phosphatase activity protein kinase binding protein domain specific binding ankyrin binding potassium ion binding sodium ion binding ADP binding phosphatidylinositol 3-kinase binding chaperone binding steroid hormone binding ATPase binding drug binding ATPase activity nucleotide binding hydrolase activity metal ion binding cation-transporting ATPase activity primary active transporter transporter
参与通路
regulation of the force of heart contraction regulation of sodium ion transport cellular sodium ion homeostasis regulation of blood pressure potassium ion import establishment or maintenance of transmembrane electrochemical gradient ATP hydrolysis coupled proton transport dephosphorylation cellular potassium ion homeostasis negative regulation of glucocorticoid biosynthetic process ion transmembrane transport sodium ion export from cell response to drug negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction relaxation of cardiac muscle cardiac muscle contraction membrane hyperpolarization cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane transmembrane transport neurotransmitter uptake regulation of respiratory gaseous exchange by neurological system process potassium ion transport sodium ion transport regulation of smooth muscle contraction regulation of striated muscle contraction adult locomotory behavior visual learning regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion regulation of vasoconstriction response to nicotine locomotion negative regulation of striated muscle contraction ATP metabolic process negative regulation of cytosolic calcium ion concentration regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic membrane depolarization during cardiac muscle cell action potential negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity energy coupled proton transmembrane transport, against electrochemical gradient sodium ion transmembrane transport potassium ion transmembrane transport transport ion transport regulation of muscle contraction metabolic process regulation of cardiac muscle contraction by calcium ion signaling
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