Proteintech

ATP1A1 Polyclonal Antibody

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说明书
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ATP1A1 Polyclonal Antibody

产品信息

14418-1-AP

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:500-1:1,000
查看126篇已发表文章 126篇已发表文章

免疫组化 (IHC)

-
查看8篇已发表文章 8篇已发表文章

免疫组化（石蜡） (IHC (P))

1:20-1:400
-

免疫细胞化学 (ICC/IF)

1:50-1:500
查看18篇已发表文章 18篇已发表文章

免疫沉淀 (IP)

0.5-4.0 µg
查看2篇已发表文章 2篇已发表文章

其他PubMed (Misc)

-
查看1篇已发表文章 1篇已发表文章

不适用 (N/A)

-
查看3篇已发表文章 3篇已发表文章
产品规格

种属反应

Human, Mouse, Rat

已发表种属

Human, Mouse, Pig, Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

ATP1A1 Fusion Protein Ag5763 (347-680 aa encoded by BC050359)
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.3 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: TAKRMARKN CLVKNLEAVE TLGSTSTICS DKTGTLTQNR MTVAHMWFDN QIHEADTTEN QSGVSFDKTS ATWLALSRIA GLCNRAVFQA NQENLPILKR AVAGDASESA LLKCIELCCG SVKEMRERYA KIVEIPFNST NKYQLSIHKN PNTSEPQHLL VMKGAPERIL DRCSSILLHG KEQPLDEELK DAFQNAYLEL GGLGERVLGF CHLFLPDEQF PEGFQFDTDD VNFPIDNLCF VGLISMIDPP RAAVPDAVGK CRSAGIKVIM VTGDHPITAK AIAKGVGIIS EGNETVEDIA ARLNIPVSQV NPRDAKACVV HGSDLKDMTS EQLDD (347-680 aa encoded by BC050359)

靶标信息

The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Multiple transcript variants encoding different isoforms have been found for this gene.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: ATP1B; ATPase, Na+/K+ transporting, alpha 1 polypeptide; ATPase, Na+K+ transporting, alpha 1; MGC1798; Na(+)/K(+) ATPase alpha-1 subunit; Na+/K+ ATPase 1; Na+/K+ ATPase Alpha; Na, K-ATPase, alpha-A catalytic polypeptide; Na,K-ATPase alpha-1 subunit; Na,K-ATPase catalytic subunit alpha-A protein; RP4-655J12.1; Sodium Potassium ATPase; Sodium pump subunit alpha-1; sodium-potassium ATPase catalytic subunit alpha-1; sodium-potassium-ATPase, alpha 1 polypeptide; Sodium/potassium-transporting ATPase subunit alpha-1

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基因别名: ATP1A1; Atpa-1; BC010319; Nkaa1b

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UniProt ID: (Human) P05023, (Rat) P06685, (Mouse) Q8VDN2

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Entrez Gene ID: (Human) 476, (Rat) 24211, (Mouse) 11928

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功能
sodium:potassium-exchanging ATPase activity protein binding ATP binding phosphatase activity protein kinase binding protein domain specific binding ankyrin binding potassium ion binding sodium ion binding ADP binding phosphatidylinositol 3-kinase binding chaperone binding steroid hormone binding nucleotide binding hydrolase activity metal ion binding primary active transporter
参与通路
regulation of the force of heart contraction regulation of sodium ion transport cellular sodium ion homeostasis regulation of blood pressure potassium ion import establishment or maintenance of transmembrane electrochemical gradient ATP hydrolysis coupled proton transport dephosphorylation cellular potassium ion homeostasis negative regulation of glucocorticoid biosynthetic process ion transmembrane transport sodium ion export from cell response to drug negative regulation of heart contraction positive regulation of heart contraction positive regulation of striated muscle contraction relaxation of cardiac muscle cardiac muscle contraction membrane hyperpolarization cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction membrane repolarization membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction response to glycoside regulation of cardiac conduction potassium ion import across plasma membrane potassium ion transport sodium ion transport energy coupled proton transmembrane transport, against electrochemical gradient sodium ion transmembrane transport potassium ion transmembrane transport transport ion transport
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