Invitrogen

ATP1B1 Monoclonal Antibody (M17-P5-F11)

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60 篇参考文献
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ATP1B1 Monoclonal Antibody (M17-P5-F11)

产品信息

MA3-930

应用
建议稀释比
已发表文章

免疫印迹 (WB)

1:1,000-1:10,000
查看47篇已发表文章 47篇已发表文章

免疫组化 (IHC)

-
查看3篇已发表文章 3篇已发表文章

免疫组化（石蜡） (IHC (P))

1:200
查看1篇已发表文章 1篇已发表文章

免疫细胞化学 (ICC/IF)

Assay-dependent
查看4篇已发表文章 4篇已发表文章

免疫沉淀 (IP)

Assay-dependent
-

亲和纯化 (AP)

-
查看3篇已发表文章 3篇已发表文章

其他PubMed (Misc)

-
查看2篇已发表文章 2篇已发表文章
产品规格

种属反应

Dog, Human, Mouse, Sheep, Pig

已发表种属

C. elegans, Dog, Fruit fly, Human, Invertebrate, Mouse, Sheep

宿主/亚型

Mouse / IgG2a

分类

Monoclonal

类型

Antibody

克隆号

M17-P5-F11

抗原

Purified lamb kidney beta sodium/potassium ATPase.
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偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS with 1mg/mL BSA

内含物

0.05% sodium azide

保存条件

-20°C, Avoid Freeze/Thaw Cycles

运输条件

Ambient (domestic); Wet ice (international)

RRID

AB_2060990

产品详细信息

MA3-930 detects sodium/potassium ATPase beta 1 from mouse, human, sheep, canine, and pig tissues. This antibody does not recognize the beta 1 or beta 2 subunit in rat.

MA3-930 has been successfully used in Western blot and immunohistochemistry and immunocytochemistry procedures. By Western blot, this antibody detects an ~42 kDa protein in liver samples and ~55 kDa in kidney samples representing beta sodium/potassium ATPase in sheep liver extract. Immunohistochemical staining of the sodium/potassium ATPase with MA3-930 yields a pattern consistent with plasma membrane localization.

The MA3-930 antigen is purified lamb kidney sodium/potassium ATPase beta. This antibody recognizes and epitope between amino acid residues 195-199 of sheep sodium/potassium ATPase beta 1.

靶标信息

The protein encoded by this gene belongs to the family of Na+/K+ and H+/K+ ATPases beta chain proteins, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The beta subunit regulates, through assembly of alpha/beta heterodimers, the number of sodium pumps transported to the plasma membrane. The glycoprotein subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes a beta 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been described, but their biological validity is not known.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

生物信息学

蛋白别名: adenosinetriphosphatase; ATPase beta subunit; ATPase, Na+/K+ transporting, beta 1 polypeptide; Beta 1-subunit of Na(+),K(+)-ATPase; MGC1798; Na+, K+-ATPase; Na+, K+-ATPase beta-subunit; Na+/K+ ATPase Beta; Na, K-ATPase beta-1 polypeptide; OTTHUMP00000032537; OTTHUMP00000032538; Sodium Potassium ATPase; sodium pump subunit beta-1; sodium-potassium ATPase subunit beta 1 (non-catalytic); sodium/potassium ATPase beta subunit; sodium/potassium-dependent ATPase beta-1 subunit; Sodium/potassium-dependent ATPase subunit beta-1; sodium/potassium-transporting ATPase beta-1 chain; Sodium/potassium-transporting ATPase subunit beta-1; unnamed protein product

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基因别名: ATP1B; ATP1B1; Atp4b; Atpb; Atpb-1; NKbeta1

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UniProt ID: (Sheep) P05028, (Pig) P05027, (Human) P05026, (Mouse) P14094

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Entrez Gene ID: (Sheep) 443384, (Dog) 403966, (Pig) 396898, (Human) 481, (Mouse) 11931

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功能
sodium:potassium-exchanging ATPase activity protein binding ATP binding protein C-terminus binding drug binding ATPase activity protein kinase binding potassium ion binding sodium ion binding ATPase binding ATPase activator activity MHC class II protein complex binding primary active transporter
参与通路
cell adhesion establishment or maintenance of transmembrane electrochemical gradient positive regulation of ATPase activity cellular calcium ion homeostasis cellular sodium ion homeostasis regulation of gene expression regulation of cardiac muscle contraction by calcium ion signaling cellular potassium ion homeostasis sodium ion export from cell ATP metabolic process protein stabilization transmembrane transport relaxation of cardiac muscle cardiac muscle contraction protein localization to plasma membrane membrane repolarization positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of calcium:sodium antiporter activity positive regulation of potassium ion import potassium ion import across plasma membrane response to hypoxia positive regulation of defense response to virus by host potassium ion import ion transmembrane transport protein transport into plasma membrane raft leukocyte migration membrane repolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction ATP hydrolysis coupled transmembrane transport mitophagy in response to mitochondrial depolarization xenophagy regulation of cardiac conduction blastocyst development transport ion transport potassium ion transport sodium ion transport metal ion transport regulation of calcium ion transmembrane transport
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