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Invitrogen
ATP2C2 Polyclonal Antibody
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产品信息
PA5-21127
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
A 19 amino acid peptide near the amino terminus of human ATP2C2.
偶联物
形式
Liquid
浓度
1 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS
内含物
0.02% sodium azide
保存条件
Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
A suggested positive control is NIH-3T3 cell lysate.
PA5-21127 can be used with blocking peptide PEP-1241.
靶标信息
ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ATPase 2C2; ATPase, Ca++ transporting, type 2C, member 2; Ca(2+)/Mn(2+)-ATPase 2C2; Calcium-transporting ATPase type 2C member 2; Secretory pathway Ca(2+)-ATPase 2; Secretory pathway Ca(2+)-transporting ATPase type 2; secretory pathway Ca2+-ATPase; secretory pathway calcium ATPase 2; SPCA2
基因别名: 1810010G06Rik; ATP2C2; KIAA0703; mKIAA0703; SPCA2
UniProt ID: (Human) O75185, (Mouse) A7L9Z8
Entrez Gene ID: (Human) 9914, (Mouse) 69047
