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Proteintech
AUH Polyclonal Antibody
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产品信息
17079-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AUH Fusion Protein Ag11265 (1-310 aa encoded by BC020722)
偶联物
形式
Liquid
浓度
0.19 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MAAAVAAAP GALGSLHAGG ARLVAACSAW LCPGLRLPGS LAGRRAGPAI WAQGWVPAAG GPAPKRGYSS EMKTEDELRV RHLEEENRGI VVLGINRAYG KNSLSKNLIK MLSKAVDALK SDKKVRTIII RSEVPGIFCA ANLPVPTIAA IDGLALGGGL ELALACDIRV AASSAKMGLV ETKLAIIPGG GGTQRLPRAI GMSLAKELIF SARVLDGKEA KAVGLISHVL EQNQEGDAAY RKALDLAREF LPQGPVAMRV AKLAINQGME VDLVTGLAIE EACYAQTIPT KDRLEGLLAF KEKRPPRYKG E (1-310 aa encoded by BC020722)
靶标信息
The methylglutaconyl-CoA hydratase, mitochondrial protein binds to the AU-rich element (ARE), a common element found in the 3' UTR of rapidly decaying mRNA such as c-fos, c-myc and granulocyte/ macrophage colony stimulating factor. ARE elements are involved in directing RNA to rapid degradation and deadenylation. AUH is also homologous to enol-CoA hydratase, an enzyme involved in fatty acid degradation, and has been shown to have intrinsic hydratase enzymatic activity. AUH is thus a bifunctional chimera between RNA binding and metabolic enzyme activity. A possible subcellular localization in the mitochondria has been demonstrated for the mouse homolog of this protein which shares 92% identity with the human protein. It has been suggested that AUH may have a novel role as a mitochondrial located AU-binding protein. Human AUH is expressed as a single mRNA species of 1.8 kb, and translated as a 40- kDa precursor protein which is subsequently processed to a 32- kDa mature form.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 3-methylglutaconyl-CoA hydratase; 3-MG-CoA hydratase; AU RNA binding protein/enoyl-coenzyme A hydratase; AU RNA-binding protein/enoyl-Coenzyme A hydratase; AU-binding enoyl-CoA hydratase; AU-binding protein/Enoyl-CoA hydratase; AU-specific RNA-binding enoyl-CoA hydratase; Itaconyl-CoA hydratase; Methylglutaconyl-CoA hydratase, mitochondrial; muAUH
基因别名: AUH; C77140; W91705
UniProt ID: (Human) Q13825, (Mouse) Q9JLZ3
Entrez Gene ID: (Human) 549, (Rat) 361215, (Mouse) 11992
