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Proteintech
AVEN Polyclonal Antibody
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产品信息
25846-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AVEN Fusion Protein Ag23020 (1-362 aa encoded by BC010488)
偶联物
形式
Liquid
浓度
0.38 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: MQAERGARG GRGRRPGRGR PGGDRHSERP GAAAAVARGG GGGGGGDGGG RRGRGRGRGF RGARGGRGGG GAPRGSRREP GGWGAGASAP VEDDSDAETY GEENDEQGNY SKRKIVSNWD RYQDIEKEVN NESGESQRGT DFSVLLSSAG DSFSQFRFAE EKEWDSEASC PKQNSAFYVD SELLVRALQE LPLCLRLNVA AELVQGTVPL EVPQVKPKRT DDGKGLGMQL KGPLGPGGRG PIFELKSVAA GCPVLLGKDN PSPGPSRDSQ KPTSPLQSAG DHLEEELDLL LNLDAPIKEG DNILPDQTSQ DLKSKEDGEV VQEEEVCAKP SVTEEKNMEP EQPSTSKNVT EEELEDWLDS MIS (1-362 aa encoded by BC010488)
靶标信息
Apoptosis plays a major role in normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. Aven is a recently discovered protein that blocks apoptosis induced by Apaf-1 and caspase-9. It is thought that Aven functions by binding to Bcl-xL, an antiapoptotic member of the Bcl-2 family, and to Apaf-1, possibly interfering with the ability of Apaf-1 to self-associate, suggesting that Aven impedes Apaf-1-mediated caspase activation. Higher levels of Aven mRNA are seen in patients with acute leukemia than in control patients, suggesting that Aven may be useful as a prognostic indicator in leukemia patients.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: apoptosis, caspase activation inhibitor; Cell death regulator Aven; programmed cell death 12
基因别名: AVEN; PDCD12
UniProt ID: (Human) Q9NQS1
Entrez Gene ID: (Human) 57099
