Proteintech

AXIN1 Monoclonal Antibody (1C4E8), CoraLite® Plus 488

查看其他9个AXIN1抗体

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说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持
说明书
实验方案
问题与答案
技术支持

产品信息

CL488-68093

应用
建议稀释比
已发表文章

流式细胞分析 (Flow)

0.40 µg/10^6 cells in a 100 µL suspension
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产品规格

种属反应

Human, Mouse, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1C4E8

抗原

AXIN1 fusion protein Ag10079

偶联物

CoraLite® Plus 488 CoraLite® Plus 488 CoraLite® Plus 488

激发/发射光谱

493/522 nm

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein G

保存液

PBS, pH 7.3, with 0.5% BSA, 50% glycerol

内含物

0.05% ProClin 300

保存条件

-20°C, store in dark

运输条件

Wet ice

产品详细信息

Immunogen sequence: MNIQEQGFP LDLGASFTED APRPPVPGEE GELVSTDPRP ASYSFCSGKG VGIKGETSTA TPRRSDLDLG YEPEGSASPT PPYLKWAESL HSLLDDQDGI SLFRTFLKQE GCADLLDFWF ACTGFRKLEP CDSNEEKRLK LARAIYRKYI LDNNGIVSRQ TKPATKSFIK GCIMKQLIDP AMFDQAQTEI QATMEENTYP SFLKSDIYLE YTRTGSESPK VCSDQSSGSG TGKGISGYLP TLNEDEEWKC DQDMDEDDGR DAAPPGRLPQ KLLLETAAPR VSSSRRYSEG REFRYGSWRE PVNPYYVNAG YALAPATSAN DSEQQSLSSD ADTLSLTDSS VDGIPPYRIR KQ

靶标信息

AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

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引用该产品

生物信息学

蛋白别名: Axin-1; Axis inhibition protein 1; axis inhibitor 1; fused, mouse, homolog of; GSK-3beta interacting protein rAxin; hAxin; LA16c-314G4.3; MGC52315; Protein Fused; protein phosphatase 1, regulatory subunit 49; rAxin

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基因别名: AI316800; AXIN; AXIN1; Fu; fused; Kb; Ki; kinky; knobbly; PPP1R49

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UniProt ID: (Human) O15169, (Rat) O70239, (Mouse) O35625

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Entrez Gene ID: (Human) 8312, (Rat) 79257, (Mouse) 12005

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功能
signal transducer activity GTPase activator activity protein binding beta-catenin binding enzyme binding protein kinase binding receptor signaling complex scaffold activity ubiquitin protein ligase binding protein complex scaffold identical protein binding protein homodimerization activity SMAD binding armadillo repeat domain binding I-SMAD binding p53 binding receptor binding protein C-terminus binding protein domain specific binding protein self-association R-SMAD binding scaffold/adaptor protein
参与通路
optic placode formation positive regulation of protein phosphorylation apoptotic process activation of JUN kinase activity determination of left/right symmetry cell death dorsal/ventral axis specification positive regulation of peptidyl-threonine phosphorylation Wnt signaling pathway forebrain anterior/posterior pattern specification Wnt-activated signaling pathway involved in forebrain neuron fate commitment negative regulation of Wnt signaling pathway olfactory placode formation cytoplasmic microtubule organization positive regulation of protein ubiquitination activation of protein kinase activity positive regulation of peptidyl-serine phosphorylation negative regulation of transcription elongation from RNA polymerase II promoter regulation of catenin import into nucleus proteasome-mediated ubiquitin-dependent protein catabolic process positive regulation of GTPase activity cellular protein complex assembly negative regulation of fat cell differentiation positive regulation of protein catabolic process positive regulation of transcription, DNA-templated positive regulation of JNK cascade embryonic eye morphogenesis axial mesoderm formation positive regulation of ubiquitin-protein transferase activity muscle cell development canonical Wnt signaling pathway embryonic skeletal joint morphogenesis canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation cellular response to organic cyclic compound negative regulation of canonical Wnt signaling pathway Wnt signaling pathway involved in somitogenesis positive regulation of canonical Wnt signaling pathway beta-catenin destruction complex assembly beta-catenin destruction complex disassembly positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process protein polyubiquitination in utero embryonic development regulation of protein phosphorylation nucleocytoplasmic transport sensory perception of sound adult walking behavior dorsal/ventral pattern formation hemoglobin metabolic process protein catabolic process positive regulation of transforming growth factor beta receptor signaling pathway positive regulation of proteasomal ubiquitin-dependent protein catabolic process erythrocyte homeostasis post-anal tail morphogenesis termination of G-protein coupled receptor signaling pathway positive regulation of JUN kinase activity positive regulation of protein kinase activity axial mesoderm development neurological system process negative regulation of protein metabolic process protein homooligomerization genetic imprinting signal transduction multicellular organism development cell differentiation
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