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Invitrogen
AXIN1 Monoclonal Antibody (E.882.7)
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AXIN1 Antibody (MA5-14790) in WB
Western blot was performed using Anti-Axin1 Monoclonal Antibody (Product # MA5-14790) and a 110 kDa band corresponding to Axin1 was observed across cell lines. Whole cell extracts (30 µg lysate) of MCF-7 (Lane 1), NTERA-2 cl.D1 (Lane 2), U-937 (Lane 3), HEK-293 (Lane 4), HeLa (Lane 5), HCT 116 (Lane 6), U-87MG (Lane 7) and tissue lysate of Mouse Brain (Lane 8) were electrophoresed using NuPAGE™ 4-12% Bis-Tris Protein Gel (Product # NP0322BOX). Resolved proteins were then transferred onto a nitrocellulose membrane (Product # IB23001) by iBl... View More
产品信息
MA5-14790
产品规格
宿主/亚型
Rabbit
/ IgG
分类
Monoclonal
类型
Antibody
克隆号
E.882.7
抗原
Recombinant protein consisting of the N-terminal region of human Axin1
偶联物
形式
Liquid
保存条件
-20°C
运输条件
Wet ice
RRID
产品详细信息
It is not recommended to aliquot this antibody.
靶标信息
AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a disheveled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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