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Proteintech
AXL Polyclonal Antibody
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产品信息
13196-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse
已发表种属
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
AXL Fusion Protein Ag3898 (545-894 aa encoded by BC032229)
偶联物
形式
Liquid
浓度
0.21 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
This antibody detects a single band at 140 kDa, which is considered to represent the auto-phosphorylated form of endogenous Axl.
Immunogen sequence: GEFGAVMEG QLNQDDSILK VAVKTMKIAI CTRSELEDFL SEAVCMKEFD HPNVMRLIGV CFQGSERESF PAPVVILPFM KHGDLHSFLL YSRLGDQPVY LPTQMLVKFM ADIASGMEYL STKRFIHRDL AARNCMLNEN MSVCVADFGL SKKIYNGDYY RQGRIAKMPV KWIAIESLAD RVYTSKSDVW SFGVTMWEIA TRGQTPYPGV ENSEIYDYLR RGNRLKQPAD CLDGLYALMS RCWELNPQDR PSFTELREDL ENTLKALPPA QEPDEILYVN MDEGGGYPEP PGAAGGADPP TQPDPKDSCS CLTAAEVHPA GRYVLCPSTT PSPAQPADRG SPAAPGQEDG A (545-894 aa encoded by BC032229)
靶标信息
AXL is a chronic myelogenous leukemia-associated oncogene that is also associated with colon cancer and melanoma. The AXL protein is a receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6, and is involved in the stimulation of cell proliferation. TAM receptors are also involved in phagocytosis of apoptotic cells. Mice lacking all three TAM receptors have several degenerative phenotypes linked to inefficient removal of apoptotic cells and membranes (e.g., in the retina and the male reproductive tract) and develop a severe autoimmune phenotype akin to systemic lupus erythematosus, including the production of broad spectrum auto-antibodies. In addition, Axl may function as a putative entry receptor for filoviruses. Axl is also used to identify a specific subpopulation of human blood dendritic cells, also referred to as Siglec 6+/Axl+ dendritic cells. Cellular expression of Axl can be upregulated by TLR ligands, such as LPS or poly I:C. Soluble Axl is generated by proteolytic cleavage of the membrane form. Increased plasma levels may be indicative of inflammation and cancer.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Adhesion-related kinase; AXL oncogene; AXL transforming sequence/gene; AZF1; oncogene AXL; sAXL; soluble AXL; Tyrosine-protein kinase receptor UFO; ufo oncogene homolog
基因别名: AI323647; ARK; AXL; JTK11; Tyro7; UFO
UniProt ID: (Human) P30530, (Mouse) Q00993
Entrez Gene ID: (Human) 558, (Mouse) 26362
virus receptor activity
phosphatidylserine binding
protein tyrosine kinase activity
transmembrane receptor protein tyrosine kinase activity
protein binding
ATP binding
protein heterodimerization activity
nucleotide binding
protein kinase activity
kinase activity
transferase activity
transferase activity, transferring phosphorus-containing groups
myosin heavy chain binding
phosphatidylinositol 3-kinase binding
transmembrane signal receptor
neuron migration
natural killer cell differentiation
positive regulation of cytokine-mediated signaling pathway
blood vessel remodeling
phagocytosis
inflammatory response
signal transduction
spermatogenesis
peptidyl-tyrosine phosphorylation
forebrain cell migration
platelet activation
cellular response to extracellular stimulus
negative regulation of interferon-gamma production
negative regulation of tumor necrosis factor production
positive regulation of natural killer cell differentiation
secretion by cell
erythrocyte homeostasis
substrate adhesion-dependent cell spreading
cellular response to interferon-alpha
ovulation cycle
apoptotic cell clearance
protein kinase B signaling
negative regulation of neuron apoptotic process
innate immune response
viral entry into host cell
vascular endothelial growth factor receptor signaling pathway
cell maturation
positive regulation of pinocytosis
negative regulation of lymphocyte activation
positive regulation of protein kinase B signaling
vagina development
cellular response to lipopolysaccharide
dendritic cell differentiation
negative regulation of dendritic cell apoptotic process
immune system process
protein phosphorylation
enzyme linked receptor protein signaling pathway
phosphorylation
cell differentiation
negative regulation of apoptotic process
cellular response to hydrogen peroxide
