Search Thermo Fisher Scientific
图: 1 / 4
Positive Control: SW1990 cell lysate, PANC-1 cell lysate, mouse colon tissue lysate, rat liver tissue lysate, rat heart tissue lysate, SiHa, human placenta tissue, mouse placenta tissue.
Subcellular Location: Secreted.
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Activin A mutations are associated with fibrodysplasia ossificans progressive.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: activin A; Activin beta-A chain; EDF; erythroid differentiation factor; Erythroid differentiation protein; follicle-stimulating hormone-releasing protein; FSH-releasing protein; Inhibin beta A chain; inhibin, beta A (activin A, activin AB alpha polypeptide); Inhibin, beta-1
基因别名: EDF; FRP; INHBA
UniProt ID: (Human) P08476, (Rat) P18331, (Mouse) Q04998
Entrez Gene ID: (Human) 3624, (Rat) 29200, (Mouse) 16323