Product References
Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities.
Cellular and molecular neurobiology
Lauro F,Giancotti LA,Kolar G,Harada CM,Harmon TA,Garrett TJ,Salvemini D
PA5-27399 was used in Western Blot to show that SEW287-induced behavioral hypersensitivity is associated with increased expression of ADK in astrocytes of the dorsal horn of the spinal cord.
Tue Nov 01 00:00:00 EDT 2022
Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus.
International journal of molecular sciences
Fábera P,Uttl L,Kubová H,Tsenov G,Mareš P
PA5-27399 was used in Western Blotting to elucidate the changes in ADK isoform expression after LiCl/pilocarpine SE and whether potential changes, as well as inhibition of ADK by 5-iodotubercidin (5-ITU), may contribute to changes in hippocampal excitability during brain development.
Thu Feb 24 00:00:00 EST 2022
Adenosine Kinase Isoforms in the Developing Rat Hippocampus after LiCl/Pilocarpine Status Epilepticus.
International journal of molecular sciences
Fábera P,Uttl L,Kubová H,Tsenov G,Mareš P
PA5-27399 was used in Western Blotting to elucidate the changes in ADK isoform expression after LiCl/pilocarpine SE and whether potential changes, as well as inhibition of ADK by 5-iodotubercidin (5-ITU), may contribute to changes in hippocampal excitability during brain development.
Thu Feb 24 00:00:00 EST 2022
Chronic Morphine-Induced Changes in Signaling at the A3 Adenosine Receptor Contribute to Morphine-Induced Hyperalgesia, Tolerance, and Withdrawal.
The Journal of pharmacology and experimental therapeutics
Doyle TM,Largent-Milnes TM,Chen Z,Staikopoulos V,Esposito E,Dalgarno R,Fan C,Tosh DK,Cuzzocrea S,Jacobson KA,Trang T,Hutchinson MR,Bennett GJ,Vanderah TW,Salvemini D
PA5-27399 was used in Western Blotting to demonstrate that opioid-induced hyperalgesia and antinociceptive tolerance in rats is associated with a twofold increase in adenosine kinase expression in the dorsal horn of the spinal cord.
Sat Aug 01 00:00:00 EDT 2020
Chemotherapy-induced pain is promoted by enhanced spinal adenosine kinase levels through astrocyte-dependent mechanisms.
Pain
Wahlman C,Doyle TM,Little JW,Luongo L,Janes K,Chen Z,Esposito E,Tosh DK,Cuzzocrea S,Jacobson KA,Salvemini D
PA5-27399 was used in Western Blotting to strengthen the pharmacological rationale for clinical evaluation of A3AR agonists already in advanced clinical trials as anticancer agents as an adjunct to chemotherapy.
Fri Jun 01 00:00:00 EDT 2018