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Invitrogen
Adenovirus Type 2 Monoclonal Antibody (4D2)
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产品信息
MA5-11222
应用
建议稀释比
已发表文章
产品规格
已发表种属
Virus
宿主/亚型
Mouse
/ IgG2a, kappa
分类
Monoclonal
类型
Antibody
克隆号
4D2
抗原
UV-irradiated Ad2 virus
偶联物
形式
Liquid
浓度
0.2 mg/mL
保存条件
4°C
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
MA5-11222 targets Adenovirus Fiber in IF and WB applications and shows reactivity with Virus samples.
The MA5-11222 immunogen is uV-irradiated Ad2 virus.
靶标信息
Adenovirus capsid proteins are synthesized in the cytoplasm and transported to the nucleus for assembly into the virus particles. The three major capsid proteins (hexon, penton base, and fiber) are synthesized late in infection. Fiber plays a crucial role in adenovirus infection by attaching the virus to a specific receptor on the cell surface. Ad2 and Ad5 fibers are proposed to consist of three domains: an N-terminal tail that interacts with penton base, a shaft composed of 22 repeats of a 15 amino acid segment that forms beta-sheet and beta-bends, and a knob at the C-terminus that contains the type-specific antigen and is responsible for binding to the cell surface receptor. It is shown that the fiber of Ad2 is most likely a trimer when found on the viron.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
