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Invitrogen
Adiponectin Recombinant Rabbit Monoclonal Antibody (11H4L4)
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Adiponectin Antibody (701148) in ICC/IF
Immunofluorescence analysis of Adiponectin was performed using 70% confluent log phase ADSC differentiated to Adipocytes then treated with PTI (1X for 4hrs). The cells were fixed with 4% paraformaldehyde for 10 minutes, permeabilized with 0.1% Triton™ X-100 for 15 minutes, and blocked with 2% BSA for 45 minutes at room temperature. The cells were labeled with Adiponectin Recombinant Rabbit Monoclonal Antibo... View More
产品信息
701148
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
11H4L4
抗原
Recombinant protein corresponding to amino acids 57-244 of human adiponectin
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
AB_2532410
产品详细信息
Intact IgG appears on a non-reducing gel as ~150 kDa band and upon reduction generating a ~25 kDa light chain band and a ~50 kDa heavy chain.
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Adiponectin is a protein hormone secreted exclusively by adipocytes that regulates the metabolism of lipids and glucose. Adiponectin has been shown to play a role in various physiological processes including homeostasis and obesity. Decreased levels of adiponectin are associated with obese individuals as well as insulin resistance and hyperinsulinemia (type 2 diabetes). In mice adiponectin has been shown to improve insulin signaling, thus ameliorating insulin resistance. Through activation of AMP kinase and PPAR-alpha, adiponectin can increase fatty acid transport, oxidation, and dissipation in skeletal muscle, leading to a reduction of intramyocellular lipid levels and thus improved insulin signaling.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: 30 kDa adipocyte complement-related protein; ACRP30; adipocyte complement related protein; adipocyte complement related protein of 30 kDa; Adipocyte complement-related 30 kDa protein; adipocyte, C1Q and collagen domain containing; Adipocyte, C1q and collagen domain-containing protein; Adipocyte-specific protein AdipoQ; Adiponectin; Adipose most abundant gene transcript 1 protein; adipose specific collagen-like factor; ADPIOQ; apM-1; Gelatin-binding protein; gelatin-binding protein 28
基因别名: 30kDa; ACDC; ACRP30; Ad; adipo; ADIPOQ; ADIPQTL1; ADPN; APM-1; APM1; APN; GBP28
UniProt ID: (Human) Q15848, (Mouse) Q60994
Entrez Gene ID: (Human) 9370, (Rat) 246253, (Mouse) 11450
response to hypoxia
positive regulation of protein phosphorylation
glucose metabolic process
fatty acid beta-oxidation
response to nutrient
circadian rhythm
response to sucrose
response to glucose
positive regulation of signal transduction
negative regulation of platelet-derived growth factor receptor signaling pathway
positive regulation of protein kinase A signaling
negative regulation of macrophage derived foam cell differentiation
negative regulation of tumor necrosis factor-mediated signaling pathway
positive regulation of cholesterol efflux
regulation of glucose metabolic process
response to activity
negative regulation of smooth muscle cell migration
fatty acid oxidation
negative regulation of cell migration
negative regulation of granulocyte differentiation
response to nutrient levels
negative regulation of protein autophosphorylation
positive regulation of cellular protein metabolic process
negative regulation of tumor necrosis factor production
positive regulation of interleukin-8 production
cellular response to insulin stimulus
positive regulation of myeloid cell apoptotic process
adiponectin-activated signaling pathway
negative regulation of heterotypic cell-cell adhesion
low-density lipoprotein particle clearance
response to tumor necrosis factor
cellular response to drug
response to drug
glucose homeostasis
positive regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of MAP kinase activity
response to ethanol
negative regulation of fat cell differentiation
negative regulation of macrophage differentiation
negative regulation of low-density lipoprotein particle receptor biosynthetic process
negative regulation of gluconeogenesis
negative regulation of blood pressure
positive regulation of blood pressure
positive regulation of protein kinase activity
negative regulation of transcription, DNA-templated
positive regulation of fatty acid metabolic process
positive regulation of glucose import
negative regulation of hormone secretion
negative regulation of smooth muscle cell proliferation
negative regulation of inflammatory response
positive regulation of peptidyl-tyrosine phosphorylation
negative regulation of phagocytosis
negative regulation of synaptic transmission
brown fat cell differentiation
protein homooligomerization
response to glucocorticoid
membrane depolarization
membrane hyperpolarization
protein heterotrimerization
negative regulation of ERK1 and ERK2 cascade
response to linoleic acid
detection of oxidative stress
cellular response to cAMP
positive regulation of monocyte chemotactic protein-1 production
cellular response to epinephrine stimulus
protein localization to plasma membrane
negative regulation of intracellular protein transport
negative regulation of receptor binding
negative regulation of DNA biosynthetic process
positive regulation of glycogen (starch) synthase activity
positive regulation of metanephric glomerular visceral epithelial cell development
positive regulation of cAMP-dependent protein kinase activity
positive regulation of renal albumin absorption
negative regulation of platelet-derived growth factor receptor-alpha signaling pathway
negative regulation of metanephric mesenchymal cell migration
generation of precursor metabolites and energy
