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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
2 µg/mL | - |
免疫组化 (IHC) |
Assay-dependent | - |
免疫细胞化学 (ICC/IF) |
2 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Mouse, Rat |
宿主/亚型 |
Mouse / IgG1 |
分类 |
Monoclonal |
类型 |
Antibody |
克隆号 |
Agr 33 |
抗原 |
Recombinant rat agrin, C-terminal construct. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1 mg/mL |
纯化类型 |
Protein G |
保存液 |
PBS, pH 7.2, with 0.1mM PMSF, 50% glycerol |
内含物 |
no preservative |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_557527 |
MA1-20378 detects agrin in mouse and rat samples.
Agrin is a molecule that resides in the basal lamina of muscle cells and directs key events in post synaptic differentiation. Most notably, Agrin is responsible for the clustering of acetylcholine receptors (AChRs) on the cell surface and their localization to the neuromuscular junction. Several Agrin variants have been identified which arise from alternative mRNA splicings. Agrin splice forms having inserts at two sites in the carboxy terminus designated "y" and "z" display a high affinity for AChRs, while splice forms lacking these inserts associate with AChRs weakly. Muscle alpha-dystroglycan has been postulated to be the receptor for the clustering activity of agrin; however, this is a point of contention. Tyrosine phosphorylation has been implicated as a required early step in AChR aggregation. Interestingly, a unique receptor tyrosine kinase, designated MuSK, has been discovered that interacts with Agrin and is specifically localized to developing muscle.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Agrin; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 22 kDa fragment; Agrin C-terminal 90 kDa fragment; Agrin N-terminal 110 kDa subunit; C22; C90; RP23-139J18.2
基因别名: AGR; Agrin; Agrn; nmf380
UniProt ID: (Rat) P25304
Entrez Gene ID: (Mouse) 11603, (Rat) 25592
分子生物学功能:
protease inhibitor
