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Invitrogen
Albendazole-2-aminosulfone Recombinant Mouse Monoclonal Antibody (4F7)
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Albendazole-2-aminosulfone Antibody (MA566646) in SDS-PAGE
SDS-PAGE characterization of Albendazole-2-aminosulfone under reducing conditions. Lane M: Protein marker (kDa); Lane ABZNH2SO2: Purified Albendazole-2-aminosulfone Recombinant Monoclonal (Product # MA566646). Albendazole-2-aminosulfone showing heavy chain (~50 kDa) and light chain (~25 kDa). Gels were stained with Coomassie Brilliant Blue R-465.
产品信息
MA566646
产品规格
种属反应
Chemical
宿主/亚型
Mouse
/ IgG
Expression System
CHO cells
分类
Recombinant Monoclonal
类型
Antibody
克隆号
4F7
抗原
Conjugate of ABZNH2SO2 hapten and KLH.
偶联物
形式
Liquid
浓度
10.3 mg/mL
纯化类型
Protein G
保存液
PBS
内含物
0.09% sodium azide
保存条件
-20°C
运输条件
Ambient (domestic); Wet ice (international)
靶标信息
Albendazole-2-aminosulfone (ABZ-2-NH2-SO2) is a metabolite of albendazole, a broad-spectrum anthelmintic used to treat parasitic worm infections. The compound is formed through the metabolic conversion of albendazole sulfoxide and albendazole sulfone. Albendazole-2-aminosulfone has been studied for its pharmacokinetics and tissue distribution, particularly in aquatic species such as Yellow River carp, where it is administered orally. The metabolite is also detectable in bovine milk and muscle tissue, indicating its presence in food products of animal origin. The mechanism of action of albendazole involves the inhibition of tubulin polymerization, leading to the disruption of cytoplasmic microtubules, which is crucial for the survival of parasitic worms. This metabolite, like its parent compound, contributes to the degenerative alterations in the tegument and intestinal cells of the worms, thereby diminishing their energy production and leading to their eventual death.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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