Immunogen sequence: AQVGERLMVH CDSKTGNANT DFIWVGPDNR LLEPDKEMEN FYVFHNGSLV IESPRFEDAG VYSCIAMNKQ RLLNETVDVT INVSNFTVSR S
Highest antigen sequence identity to the following orthologs: Mouse - 85%, Rat - 82%.
A novel primary response gene, Alivin 1 (ali1), is an activity-dependent gene and promotes survival of neurons. Sequence analyses reveal that rat, mouse, and human Ali1 proteins contain seven leucine-rich repeats, one IgC2-like loop and a transmembrane domain, and display homology to Kek and Trk families. Results suggest that expression of ali1 promotes depolarization-dependent survival of the granule neuron. Mouse ali1 was mapped to a locus approximately 55.3 cM from the centromere on chromosome 15 that is syntenic to positional candidate loci for familial Alzheimer's disease type 5 and Parkinson's disease 8 on human chromosome 12.
蛋白别名: adhesion molecule with Ig-like domain 2; alivin 1; Alivin-1; AMIGO-2; AMIGO2; amphoterin induced gene 2; Amphoterin-induced protein 2; DEGA; differentially expressed in gastric adenocarcinoma; Differentially expressed in gastric adenocarcinomas; transmembrane protein AMIGO2
基因别名: ALI1; AMIGO-2; AMIGO2; DEGA
UniProt ID: (Human) Q86SJ2
Entrez Gene ID: (Human) 347902