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Invitrogen
Alpha Sarcoglycan Polyclonal Antibody
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产品信息
PA5-96273
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Recombinant fusion protein containing a sequence corresponding to amino acids 60-290 of human alpha Sarcoglycan (alpha Sarcoglycan (SGCA)) (NP_0000141)
偶联物
形式
Liquid
浓度
1.58 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.01% thimerosal
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
Immunogen sequence: ITYHAHLQGH PDLPRWLRYT QRSPHHPGFL YGSATPEDRG LQVIEVTAYN RDSFDTTRQR LVLEIGDPEG PLLPYQAEFL VRSHDAEEVL PSTPASRFLS ALGGLWEPGE LQLLNVTSAL DRGGRVPLPI EGRKEGVYIK VGSASPFSTC LKMVASPDSH ARCAQGQPPL LSCYDTLAPH FRVDWCNVTL VDKSVPEPAD EVPTPGDGIL EHDPFFCPPT EAPDRDFLVD A; Positive Samples: A-549, LO2, 293T, Mouse skeletal muscle, Mouse heart, Rat skeletal muscle, Rat heart; Cellular Location: Cell membrane, Cytoplasm, Single-pass type I membrane protein, cytoskeleton, sarcolemma
靶标信息
The sarcoglycan transmembrane proteins are members of the dystrophin complex. Sarcoglycans cluster together to form a complex, which is localized in the cell membrane of skeletal, cardiac, and smooth muscle fibers. Four sarcoglycan subunit proteins, designated alpha-, beta-, gamma- and delta-sarcoglycan, form a complex on the skeletal muscle cell surface membrane. A genetic defect in any one of these proteins causes the loss or marked decrease of the whole sarcoglycan complex, which is observed in the autosomal recessive muscular dystrophy, sarcoglycanopathy. In smooth muscle, beta- and delta-sarcoglycans are associated with epsilon-sarcoglycan, a glycoprotein homologous to alpha-sarcoglycan. Additionally, a complete deficiency in delta-sarcoglycan is the cause of the Syrian hamster BIO.14 cardiomyopathy.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 50 kDa dystrophin-associated glycoprotein; 50DAG; 50kD DAG; Adhalin; Alpha-sarcoglycan; Alpha-SG; Dystroglycan 2; Dystroglycan-2; Dystroglycan2; limb girdle muscular dystrophy 2D; sarcoglycan, alpha (50kDa dystrophin-associated glycoprotein); SG alpha; SG-alpha
基因别名: 50DAG; adhalin; ADL; Asg; DAG2; DMDA2; LGMD2D; SCARMD1; SGCA
UniProt ID: (Human) Q16586, (Mouse) P82350
Entrez Gene ID: (Human) 6442, (Rat) 303468, (Mouse) 20391
