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Proteintech
Amphiphysin Polyclonal Antibody
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产品信息
13379-1-AP
应用
建议稀释比
已发表文章
产品规格
种属反应
Human,
Mouse,
Rat
已发表种属
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Amphiphysin Fusion Protein Ag4204 (346-695 aa encoded by BC034376)
偶联物
形式
Liquid
浓度
0.31 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: KKEETLLDL DFDPFKPEVT PAGSAGVTHS PMSQTLPWDL WTTSTDLVQP ASGGSFNGFT QPQDTSLFTM QTDQSMICNL AESEQAPPTE PKAEEPLAAV TPAVGLDLGM DTRAEEPVEE AVIIPGADAD AAVGTLVSAA EGAPGEEAEA ETATVPAGEG VSLEEAKIGT ETTEGAESAQ PEAEELEATV PQEKVIPSVV IEPASNHEEE GENEITIGAE PKETTEDAAP PGPTSETPEL ATEQKPIQDP QPTPSAPAMG AADQLASARE ASQELPPGFL YKVETLHDFE AANSDELTLQ RGDVVLVVPS DSEADQDAGW LVGVKESDWL QYRDLATYKG LFPENFTRRL D (346-695 aa encoded by BC034376)
靶标信息
Amphiphysins, members of the BAR (Bin-Amphiphysin-Rvsp) protein super family, play a key role in clathrin-mediated endocytosis of synaptic vesicles (SVs). All members of the BAR family share a highly conserved N-terminal BAR domain and a C-terminal Src homology (SH3) domain. Two isoforms of amphiphysin have been identified and act in concert as a heterodimer. Amphiphysins interact via its carboxy-terminal SH3 domain with dynamin, synaptojanin and clathrin. These complexes are implicated in synaptic vesicle recycling at nerve terminal. Amphiphysins were also identified as the dominant autoantigen in paraneoplastic Stiff-Man Syndrome.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: Amphiphysin; amphiphysin (Stiff-Mann syndrome with breast cancer 128kD autoantigen); amphiphysin 1; amphiphysin I; HGNC:471
基因别名: AMPH; AMPH1
UniProt ID: (Human) P49418, (Rat) O08838, (Mouse) Q7TQF7
Entrez Gene ID: (Human) 273, (Rat) 60668, (Mouse) 218038
