Proteintech

Amphiregulin Monoclonal Antibody (1A1G9)

Name: Amphiregulin Monoclonal Antibody (1A1G9)
Brand: Proteintech
SKU: 66433-1-IG

2 篇参考文献

查看其他16个Amphiregulin抗体

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

说明书

实验方案

问题与答案

技术支持

抗体检测数据 (7)

Amphiregulin Antibody in Immunohistochemistry (Paraffin) (IHC (P))

图: 1 / 7

Amphiregulin Antibody (66433-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using 66433-1-IG (Amphiregulin antibody) at dilution of 1:300 (under 40x lens) heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

Amphiregulin Antibody in Western Blot (WB)

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Immunogen image

Immunogen Image Amphiregulin Monoclonal Antibody (1A1G9)

产品信息

66433-1-IG

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:1,000-1:6,000

查看1篇已发表文章 1篇已发表文章

免疫组化（石蜡） (IHC (P))

1:50-1:500

不适用 (N/A)

查看1篇已发表文章 1篇已发表文章

产品规格

种属反应

Human, Rat

宿主/亚型

Mouse / IgG1

分类

Monoclonal

类型

Antibody

克隆号

1A1G9

抗原

Amphiregulin Fusion Protein Ag8907 (25-252 aa encoded by BC009799)

查看免疫原

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

1 mg/mL

纯化类型

Protein A

保存液

PBS, pH 7.3, with 50% glycerol

内含物

0.02% sodium azide

保存条件

-20°C

运输条件

Wet ice (domestic); Dry ice (international)

产品详细信息

Immunogen sequence: AGLDLNDTY SGKREPFSGD HSADGFEVTS RSEMSSGSEI SPVSEMPSSS EPSSGADYDY SEEYDNEPQI PGYIVDDSVR VEQVVKPPQN KTESENTSDK PKRKKKGGKN GKNRRNRKKK NPCNAEFQNF CIHGECKYIE HLEAVTCKCQ QEYFGERCGE KSMKTHSMID SSLSKIALAA IAAFMSAVIL TAVAVITVQL RRQYVRKYEG EAEERKKLRQ ENGNVHAIA (25-252 aa encoded by BC009799)

靶标信息

Amphiregulin (AR) binds to EGF-Receptor (EGFR) with lower affinity than EGF. The mature secreted form AR is an 84-amino acid residue glycosylated polypeptide growth regulator, which is generated by proteolytic processing of a 252-amino acid transmembrane precursor. Seven different polypeptide ligands, which derive from distinct genes, are capable of binding to the extracellular domain of EGFR. These ligands include EGF, TGFalpha, AR, HB-EGF, cripto-1, epiregulin, and betacellulin. All of these growth factors contain a characteristic EGF-like domain which is defined by 6 evenly spaced cysteine residues that generate 3 loops through the formation of disulfide bonds. AR protein has been localized by immunohistochemistry to the epithelium of the colon, stomach, pancreas, breast, and placenta. AR is reportedly overexpressed in human cancers of breast, colon, stomach, and pancreas.

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