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产品信息
PA5-50600
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:200-1:1,000 | - |
免疫组化（石蜡） (IHC (P)) |
1:100-1:300 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to a region derived from internal residues of human angiopoietin 4 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.4 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636053 |
产品详细信息
The antibody detects endogenous levels of total Angiopoietin 4 protein.
靶标信息
Angiopoietin-1 (Ang-1) is a secreted ligand for Tie-2, a cell surface receptor tyrosine kinase expressed in endothelial and hemopoietic cells. Ang-1 is an angiogenic factor that mediates blood vessel maturation and may be involved in endothelial development. A related protein, angiopoietin-2 (Ang-2), is a naturally occurring antagonist of Ang-1 activation of Tie-2. In adult tissue, Ang-2 expression is restricted to sites of vascular remodeling. Ang-3 and Ang-4 represent the mouse and human counterparts of the same gene locus. The structural divergence of Ang-3 and Ang-4 cause their divergent functions. Ang-3 and Ang-4 have very different distributions in their respective species, and Ang-3 appears to act as an antagonist while Ang-4 appears to function as an agonist. Ang-3 and Ang-4 share all the main structural characteristics of Ang-1 and Ang-2 and are homologous throughout the signal peptide, N-terminal region, coiled-coil segment and Fibrinogen-like domain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: AGP4; ANG-3; ANG-4; Angiopoietin-3; Angiopoietin-4; Angiopoietin3; Angiopoietin4
基因别名: ANG3; ANG4; ANGPT4
UniProt ID: (Human) Q9Y264
Entrez Gene ID: (Human) 51378
分子生物学功能:
intercellular signal molecule
angiogenesis
endothelial cell proliferation
activation of transmembrane receptor protein tyrosine kinase activity
Notch signaling pathway
positive regulation of endothelial cell migration
negative regulation of angiogenesis
negative regulation of apoptotic process
positive regulation of blood vessel endothelial cell migration
negative regulation of blood vessel endothelial cell migration
positive regulation of angiogenesis
positive regulation of peptidyl-tyrosine phosphorylation
leukocyte migration
cellular response to hypoxia
