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Invitrogen
Annexin A1 Recombinant Rabbit Monoclonal Antibody (7H46L26)
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Annexin A1 Antibody (702057) in ICC/IF
For immunofluorescence analysis, MCF-7 cells were fixed and permeabilized for detection of endogenous Annexin A1 using Anti- Annexin A1 Recombinant Rabbit Monoclonal Antibody (Product # 702057, 2 µg/mL) and labeled with Goat anti-Rabbit IgG (Heavy Chain) Superclonal Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A27034, 1:2000). Panel a) shows representative cells that were stained for detection ... View More
产品信息
702057
产品规格
种属反应
Human,
Mouse
宿主/亚型
Rabbit
/ IgG
Expression System
Expi293
分类
Recombinant Monoclonal
类型
Antibody
克隆号
7H46L26
抗原
Protein corresponding to Human ANXA1 (aa 33-346)
偶联物
形式
Liquid
浓度
0.5 mg/mL
纯化类型
Protein A
保存液
PBS, pH 7.4
内含物
0.09% sodium azide
保存条件
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
运输条件
Wet ice
RRID
产品详细信息
This antibody is predicted to react with Monkey, Dog and Rabbit
Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire.
靶标信息
Annexin I belongs to a family of Ca (2+) -dependent phospholipid binding proteins that are preferentially located on the cytosolic face of the plasma membrane. Annexin I has a molecular mass of 40 kDa, with phospholipase A2 inhibitory activity. Since phospholipase A2 is required for the biosynthesis of the potent mediators of inflammation, prostaglandins and leukotrienes, annexin I may have potential anti-inflammatory activity.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: ANAX1; Annexin A1; Annexin I; annexin I (lipocortin I); Annexin-1; Calpactin II; Calpactin-2; Chromobindin-9; lipocortin 1; Lipocortin I; p35; Phospholipase A2 inhibitory protein; RP11-71A24.1
基因别名: Anx-1; Anx-A1; ANX1; ANXA1; C430014K04Rik; Lpc-1; LPC1
UniProt ID: (Human) P04083, (Mouse) P10107
Entrez Gene ID: (Human) 301, (Mouse) 16952
single-stranded DNA binding
single-stranded RNA binding
helicase activity
receptor binding
structural molecule activity
calcium ion binding
protein binding
phospholipid binding
calcium-dependent phospholipid binding
phospholipase A2 inhibitor activity
protein binding, bridging
double-stranded DNA-dependent ATPase activity
annealing helicase activity
protein homodimerization activity
calcium-dependent protein binding
cadherin binding involved in cell-cell adhesion
phospholipase inhibitor activity
calcium-binding protein
DNA strand renaturation
neutrophil homeostasis
adaptive immune response
monocyte chemotaxis
regulation of leukocyte migration
phagocytosis
inflammatory response
signal transduction
cell surface receptor signaling pathway
G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
regulation of cell shape
response to X-ray
myoblast migration involved in skeletal muscle regeneration
peptide cross-linking
insulin secretion
keratinocyte differentiation
prostate gland development
endocrine pancreas development
positive regulation of vesicle fusion
positive regulation of prostaglandin biosynthetic process
actin cytoskeleton reorganization
response to estradiol
DNA duplex unwinding
regulation of interleukin-1 production
positive regulation of interleukin-2 production
positive regulation of neutrophil apoptotic process
DNA rewinding
gliogenesis
positive regulation of T cell proliferation
response to drug
negative regulation of apoptotic process
response to peptide hormone
estrous cycle
innate immune response
positive regulation of T-helper 1 cell differentiation
negative regulation of T-helper 2 cell differentiation
negative regulation of exocytosis
alpha-beta T cell differentiation
regulation of hormone secretion
arachidonic acid secretion
regulation of inflammatory response
cellular response to hydrogen peroxide
hepatocyte differentiation
prolactin secretion
response to interleukin-1
cellular response to glucocorticoid stimulus
granulocyte chemotaxis
positive regulation of wound healing
neutrophil clearance
positive regulation of G1/S transition of mitotic cell cycle
negative regulation of phospholipase A2 activity
negative regulation of interleukin-8 secretion
regulation of cell proliferation
positive regulation of apoptotic process
negative regulation of protein secretion
