Invitrogen

Ataxin 3 Polyclonal Antibody

Ataxin 3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Ataxin 3 Antibody (PA5-22369) in IHC (P)

Immunohistochemical analysis of paraffin-embedded H661 xenograft, using Ataxin 3 (Product # PA5-22369) antibody at 1:500 dilution. Antigen Retrieval: EDTA based buffer, pH 8.0, 15 min.

Ataxin 3 Antibody in Immunohistochemistry (IHC)

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产品信息

PA5-22369

应用

建议稀释比

已发表文章

免疫印迹 (WB)

1:500-1:3,000

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免疫组化 (IHC)

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免疫组化（石蜡） (IHC (P))

1:100-1:1,000

免疫沉淀 (IP)

Assay-dependent

产品规格

种属反应

Human, Mouse

已发表种属

Rat

宿主/亚型

Rabbit / IgG

分类

Polyclonal

类型

Antibody

抗原

Recombinant protein encompassing a sequence within the center region of human Ataxin 3. The exact sequence is proprietary.

偶联物

Unconjugated Unconjugated Unconjugated

形式

Liquid

浓度

0.36 mg/mL

纯化类型

Antigen affinity chromatography

保存液

PBS, pH 7, with 20% glycerol, 1% BSA

内含物

0.025% ProClin 300

保存条件

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.

运输条件

Ambient (domestic); Wet ice (international)

AB_11152091

产品详细信息

Recommended positive controls: SK-N-SH, SK-N-AS, mouse brain, human Ataxin3-transfected 293T.

Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (85%), Pig (99%), Chicken (89%), Sheep (98%), Bovine (98%).

Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

靶标信息

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

仅用于科研。不用于诊断过程。未经明确授权不得转售。

Product References

Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules.

Physiological reports

Cheema MU,Poulsen ET,Enghild JJ,Hoorn EJ,Fenton RA,Praetorius J

Published figure using Ataxin 3 polyclonal antibody (Product # PA5-22369) in Immunohistochemistry

Sun Sep 01 00:00:00 UTC 2013

Aldosterone and angiotensin II induce protein aggregation in renal proximal tubules.

Physiological reports

Cheema MU,Poulsen ET,Enghild JJ,Hoorn EJ,Fenton RA,Praetorius J

Published figure using Ataxin 3 polyclonal antibody (Product # PA5-22369) in Immunohistochemistry

Sun Sep 01 00:00:00 UTC 2013

生物信息学

蛋白别名: ataxin 3 variant an; ataxin 3 variant ao; ataxin 3 variant at; ataxin 3 variant e; ataxin 3 variant h; ataxin 3 variant m; ataxin 3 variant r; ataxin 3 variant ref; ataxin 3 variant y; Ataxin-3; ataxin3; josephin; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3); Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; Machado-Joseph disease protein 1; Machado-Joseph disease protein 1 homolog; olivopontocerebellar ataxia 3; spin; Spinocerebellar ataxia type 3 protein

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基因别名: 2210008M02Rik; AI463012; AI647473; AT3; ataxin-3; ATX3; ATXN3; JOS; MJD; MJD1; SCA3

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UniProt ID: (Human) P54252, (Mouse) Q9CVD2

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Entrez Gene ID: (Human) 4287, (Mouse) 110616

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