Invitrogen
This Antibody was verified by Knockout to ensure that the antibody binds to the antigen stated.
应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1:500-1:3,000 | 查看1篇已发表文章 1篇已发表文章 |
免疫组化 (IHC) |
- | 查看1篇已发表文章 1篇已发表文章 |
免疫组化(石蜡) (IHC (P)) |
1:100-1:1,000 | - |
免疫细胞化学 (ICC/IF) |
1:100-1:1,000 | - |
产品规格 | |
---|---|
种属反应 |
Human, Mouse |
已发表种属 |
Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Recombinant fragment corresponding to a region within amino acids 1 and 245 of Ataxin 3 (Uniprot ID#P54252) |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.36 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7, with 20% glycerol, 1% BSA |
内含物 |
0.025% Proclin 300 |
保存条件 |
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
RRID |
AB_11152091 |
Recommended positive controls: SK-N-SH, SK-N-AS, mouse brain, human Ataxin3-transfected 293T.
Predicted reactivity: Mouse (96%), Rat (96%), Zebrafish (85%), Pig (99%), Chicken (89%), Sheep (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: ataxin 3 variant an; ataxin 3 variant ao; ataxin 3 variant at; ataxin 3 variant e; ataxin 3 variant h; ataxin 3 variant m; ataxin 3 variant r; ataxin 3 variant ref; ataxin 3 variant y; Ataxin-3; ataxin3; josephin; Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3); Machado-Joseph disease (spinocerebellar ataxia 3, olivopontocerebellar ataxia 3, autosomal dominant, ataxin 3) homolog; Machado-Joseph disease protein 1; Machado-Joseph disease protein 1 homolog; olivopontocerebellar ataxia 3; spin; Spinocerebellar ataxia type 3 protein
基因别名: 2210008M02Rik; AI463012; AI647473; AT3; ataxin-3; ATX3; ATXN3; JOS; MJD; MJD1; SCA3
UniProt ID: (Human) P54252, (Mouse) Q9CVD2
Entrez Gene ID: (Human) 4287, (Mouse) 110616
分子生物学功能:
chromatin/chromatin-binding, or -regulatory protein
DNA metabolism protein