应用 | 建议稀释比 | 已发表文章 |
---|---|---|
免疫印迹 (WB) |
1 µg/mL | 查看3篇已发表文章 3篇已发表文章 |
免疫组化 (IHC) |
- | 查看1篇已发表文章 1篇已发表文章 |
免疫细胞化学 (ICC/IF) |
1 µg/mL | 查看1篇已发表文章 1篇已发表文章 |
免疫沉淀 (IP) |
Assay-dependent | - |
产品规格 | |
---|---|
种属反应 |
Human |
已发表种属 |
Bovine, Human, Sheep |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide derived from the N-terminal region of the human Aurora B protein. |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
0.25 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4 |
内含物 |
0.1% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2533266 |
Aurora-B kinase (AurB) is a serine/threonine kinase which is the enzymatic core of the Chromosomal Passenger Complex (CPC). This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: AIE2; AIK1; AIK3; AIM-1; AIRK3; ARK-2; ARK3; AURKC; Aurora 1; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; Aurora/IPL1-related kinase 2; EC 2.7.11.1; NP_004208; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK-1; STK13
基因别名: AIK2; AIM-1; AIM1; AIRK2; ARK2; AurB; AURKB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK1; STK12; STK5
UniProt ID: (Human) C7G533
Entrez Gene ID: (Human) 9212