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          Disclaimer

          Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.

          • Primary Antibodies ›
          • Aurora B Antibodies

          Invitrogen

          Aurora B Polyclonal Antibody

          12个已发表图片
          9 篇参考文献
          查看其他39个Aurora B抗体

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          说明书
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          问题与答案
          技术支持
          说明书
          实验方案
          问题与答案
          技术支持

          Cite Aurora B Polyclonal Antibody

          • 抗体检测数据 (3)
          • 已发表图片 (12)
          Aurora B Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.
          Aurora B Antibody in Immunocytochemistry (ICC/IF)
          Group 53 Created with Sketch.

          图: 1 / 15

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          Aurora B Antibody (36-5200) in ICC/IF

          Immunofluorescent analysis of Aurora B Antibody was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with Aurora B Antibody (Product # 36-5200) at 1µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Alexa Fluor 488 Goat Anti-Rabbit IgG Secondary Antibody (Product # A-11008) at a dilution of 1:400 for 45 minutes at room ... View More {{ $ctrl.currentElement.advancedVerification.fullName }} 验证信息 View more
          已发表图片由___提供 benchsci-logo
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          查看产品

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          Aurora B Antibody in Immunocytochemistry (ICC/IF)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Immunohistochemistry (IHC)
          Aurora B Antibody in Immunohistochemistry (IHC)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)
          Aurora B Antibody in Western Blot (WB)

          产品信息

          36-5200

          应用
          建议稀释比
          已发表文章

          免疫印迹 (WB)

          1 µg/mL
          查看6篇已发表文章 6篇已发表文章

          免疫组化 (IHC)

          -
          查看1篇已发表文章 1篇已发表文章

          免疫细胞化学 (ICC/IF)

          1 µg/mL
          查看2篇已发表文章 2篇已发表文章

          免疫沉淀 (IP)

          Assay-dependent
          -
          产品规格

          种属反应

          Human

          已发表种属

          Bovine, Human, Sheep

          宿主/亚型

          Rabbit / IgG

          分类

          Polyclonal

          类型

          Antibody

          抗原

          Synthetic peptide derived from the N-terminal region of the human Aurora B protein.
          查看免疫原

          偶联物

          Unconjugated Unconjugated Unconjugated

          形式

          Liquid

          浓度

          0.25 mg/mL

          纯化类型

          Antigen affinity chromatography

          保存液

          PBS, pH 7.4

          内含物

          0.1% sodium azide

          保存条件

          -20°C

          运输条件

          Ambient (domestic); Wet ice (international)

          RRID

          AB_2533266

          靶标信息

          The Aurora kinases associate with microtubules during chromosome movement and segregation. AURKB (Aurora B) localizes to microtubules near kinetochores, specifically to the specialized microtubules called K-fibers. This complex functions in chromosome alignment and separation, histone modification, and cytokinesis. CPC also includes three non-enzymatic subunits known as the inner centromere protein (INCENP), survivin, and borealin, which determine the activity, localization, stability, and possibly even the substrate specificity of AurB. Two CPCs exist during mitosis: one containing all four members and another consisting of INCENP and AurB. Quaternary CPC functions during chromosome alignment and cytokinesis, whereas the INCENP-AurB complex may be responsible for modifying histone H3. AurB is overexpressed in a number of tumours, including primary breast and colon tumour samples. Its expression in tumours seems to be linked with Aurora-A kinase, suggesting a feedback mechanism between the two proteins.

          仅用于科研。不用于诊断过程。未经明确授权不得转售。

          生物信息学

          蛋白别名: AIM-1; ARK-2; Aurora 1; Aurora kinase B; aurora kinase B-Sv1; aurora kinase B-Sv2; Aurora- and IPL1-like midbody-associated protein 1; aurora-1; aurora-B; aurora-related kinase 2; Aurora/IPL1-related kinase 2; protein phosphatase 1, regulatory subunit 48; serine/threonine kinase 12; Serine/threonine-protein kinase 12; Serine/threonine-protein kinase 5; Serine/threonine-protein kinase aurora-B; STK-1

          查看更多 收起

          基因别名: AIK2; AIM-1; AIM1; AIRK2; ARK2; AurB; AURKB; aurkb-sv1; aurkb-sv2; IPL1; PPP1R48; STK1; STK12; STK5

          查看更多 收起

          UniProt ID: (Human) Q96DV5

          查看更多 收起

          Entrez Gene ID: (Human) 9212

          查看更多 收起

          功能
          protein serine/threonine kinase activity protein serine/threonine/tyrosine kinase activity protein binding ATP binding histone serine kinase activity metal ion binding non-receptor serine/threonine protein kinase
          参与通路
          negative regulation of transcription from RNA polymerase II promoter negative regulation of B cell apoptotic process protein phosphorylation spindle organization sister chromatid cohesion aging cell proliferation attachment of spindle microtubules to kinetochore abscission histone modification protein sumoylation anaphase-promoting complex-dependent catabolic process spindle checkpoint negative regulation of protein binding positive regulation of telomere maintenance via telomerase negative regulation of cytokinesis positive regulation of cytokinesis protein localization to kinetochore cellular response to UV cleavage furrow formation protein ubiquitination involved in ubiquitin-dependent protein catabolic process histone H3-S28 phosphorylation protein autophosphorylation mitotic spindle midzone assembly positive regulation of telomerase activity regulation of chromosome segregation regulation of signal transduction by p53 class mediator positive regulation of telomere capping
          It has to be done as per old AB suggested Products section.
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