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Invitrogen
BAF53A/BAF53B Polyclonal Antibody
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图: 1 / 5
BAF53A/BAF53B Antibody (PA5-18272) in ICC/IF
Immunocytochemistry analysis of BAF53A/BAF53B using BAF53A/BAF53B Polyclonal Antibody (Product # PA5-18272) in paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (10 µg/mL) followed by Alexa Fluor 488 secondary antibody (2 µg/mL), showing nuclear staining. Actin filaments were stained with phalloidin (red) and the nuclear stain is DAPI (blue). Negative control: Unimmu... View More
Please note: We are reviewing Western blot images included in the antibody testing data in our catalog, including those provided by third parties. Unless expressly labeled or annotated as “raw-unedited”, Western blot images included in the antibody testing data in our catalog may have been edited, optimized or otherwise adjusted for presentation.
产品信息
PA5-18272
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Goat
/ IgG
分类
Polyclonal
类型
Antibody
抗原
Synthetic peptide sequence (YEEGGKQCVERKCP) corresponding to the C-terminus amino acids of ACTL6A / ACTL6B
偶联物
Unconjugated
Unconjugated
Unconjugated
形式
Liquid
浓度
0.5 mg/mL
规格
100 µg
纯化类型
Ammonium sulfate precipitation
保存液
TBS, pH 7.3, with 0.5% BSA
内含物
0.02% sodium azide
保存条件
-20°C, Avoid Freeze/Thaw Cycles
运输条件
Ambient (domestic); Wet ice (international)
RRID
产品详细信息
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
This antibody is tested in Peptide ELISA: antibody detection limit dilution 16,000.
靶标信息
The protein encoded by this gene is a member of a family of actin-related proteins which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: 53 kDa BRG1-associated factor A; 53 kDa BRG1-associated factor B; actin-like 6; Actin-like protein 6A; Actin-like protein 6B; actin-like protein 6B {ECO:0000250|UniProtKB:O94805}; Actin-related protein Baf53a; Actin-related protein Baf53b; actl6b {ECO:0000250|UniProtKB:O94805}; ArpN-alpha; ArpNa; ArpNalpha; ArpNbeta; BAF53A; BAF53B; BRG1-associated factor 53A; BRG1-associated factor 53B; BRG1/brm-associated factor 53A; INO80 complex subunit K; MGC5382 Arp4
基因别名: 2810432C06Rik; ACTL6; ACTL6A; ACTL6B; AI851094; ARP4; ArpNa; BAF53; BAF53A; BAF53B; C79802; INO80K; RGD1307747
UniProt ID: (Mouse) Q9Z2N8, (Rat) P86173, (Mouse) Q99MR0
Entrez Gene ID: (Mouse) 56456, (Rat) 361925, (Rat) 288563, (Mouse) 83766
RNA polymerase II core promoter proximal region sequence-specific DNA binding
RNA polymerase II distal enhancer sequence-specific DNA binding
chromatin binding
protein binding
nucleosomal DNA binding
molecular_function
actin and actin related protein
actin or actin-binding cytoskeletal protein
cytoskeletal protein
DNA repair
DNA recombination
chromatin remodeling
transcription, DNA-templated
regulation of transcription, DNA-templated
cellular response to DNA damage stimulus
nervous system development
chromatin modification
regulation of growth
ATP-dependent chromatin remodeling
histone H4 acetylation
histone H2A acetylation
regulation of mitophagy
positive regulation of protein targeting to mitochondrion
neural retina development
spinal cord development
chromatin assembly or disassembly
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