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Proteintech
BAG5 Polyclonal Antibody
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产品信息
26628-1-AP
产品规格
种属反应
Human,
Mouse,
Rat
宿主/亚型
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
抗原
BAG5 Fusion Protein Ag24320 (46-394 aa encoded by BC044216)
偶联物
形式
Liquid
浓度
0.4 mg/mL
纯化类型
Antigen affinity chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20°C
运输条件
Wet ice (domestic); Dry ice (international)
产品详细信息
Immunogen sequence: NQHPSISRL QEIQKEVKSV EQQVIGFSGL SDDKNYKKLE RILTKQLFEI DSVDTEGKGD IQQARKRAAQ ETERLLKELE QNANHPHRIE IQNIFEEAQS LVREKIVPFY NGGNCVTDEF EEGIQDIILR LTHVKTGGKI SLRKARYHTL TKICAVQEII EDCMKKQPSL PLSEDAHPSV AKINFVMCEV NKARGVLIAL LMGVNNNETC RHLSCVLSGL IADLDALDVC GRTEIRNYRR EVVEDINKLL KYLDLEEEAD TTKAFDLRQN HSILKIEKVL KRMREIKNEL LQAQNPSELY LSSKTELQGL IGQLDEVSLE KNPCIREARR RAVIEVQTLI TYIDLKEALE (46-394 aa encoded by BC044216)
靶标信息
It has been hypothesizes that the BAG-5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70's anti-apoptotic function. It is believed that BAG-5 will play an important role in the mechanisms of neuronal death. BAG-5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/ modulation of other BAG containing proteins via BAG-BAG heterodimerization.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
生物信息学
蛋白别名: BAG family molecular chaperone regulator 5; BAG-5; BAG-family molecular chaperone regulator-5; BAG-family molecular chaperone regulator-5 (BAG-5); Bcl-2-associated athanogene 5; BCL2-associated athanogene 5
基因别名: 1600025G07Rik; 4930405J06Rik; BAG-5; BAG5; KIAA0873
UniProt ID: (Human) Q9UL15, (Rat) Q5QJC9, (Mouse) Q8CI32
Entrez Gene ID: (Human) 9529, (Rat) 366734, (Mouse) 70369
negative regulation of protein ubiquitination
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of ubiquitin-protein transferase activity
negative regulation of protein refolding
neuron death
regulation of inclusion body assembly
negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
protein folding
Golgi organization
negative regulation of neuron projection development
regulation of ubiquitin-protein transferase activity
regulation of cellular response to heat
