Immunogen sequence: GVLIALLMGV NNNETCRHLS CVLSGLIADL DALDVCGRTE IRNYRREVVE DINKLLKYLD LEEEADTTKA FDLRQNHSIL KIEKVLKRMR EIKNELLQAQ NPSELYLSSK TELQGLIGQL DEVSLEKNPC IREARRRAVI EVQTLITYID LKEALEKRKL FACEEHPSHK AVWNVLGNLS EIQGEVLSFD GNRTDKNYIR LEELLTKQLL ALDAVDPQGE EKCKAARKQA VRLAQNILSY LDLKSDEWEY; Positive Samples: SH-SY5Y, MCF7, Mouse lung, Mouse testis, Rat brain, Rat lung
It has been hypothesizes that the BAG-5 protein will induce the death of nigral neurons through its predicted interaction with hsp70, which will cause increased protein aggregation and cell death by disinhibition of hsp70's anti-apoptotic function. It is believed that BAG-5 will play an important role in the mechanisms of neuronal death. BAG-5 may also be of interest due to its possible role as a modulator of the hsp70/hsp40 chaperone axis or its possible interaction and coordination of localization/ modulation of other BAG containing proteins via BAG-BAG heterodimerization.
蛋白别名: BAG family molecular chaperone regulator 5; BAG-5; BAG-family molecular chaperone regulator-5; BAG-family molecular chaperone regulator-5 (BAG-5); Bcl-2-associated athanogene 5; BCL2-associated athanogene 5
基因别名: 1600025G07Rik; 4930405J06Rik; BAG-5; BAG5; KIAA0873