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产品信息
PA5-50555
| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
1:200-1:1,000 | - |
| 产品规格 | |
|---|---|
种属反应 |
Human |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
Synthetic peptide corresponding to residues near the C terminal of human BCL2-associated athanogene 6 |
偶联物 |
Unconjugated |
形式 |
Liquid |
浓度 |
1.1 mg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS, pH 7.4, with 40% glycerol |
内含物 |
0.05% sodium azide |
保存条件 |
-20°C |
RRID |
AB_2636008 |
产品详细信息
The antibody detects endogenous levels of total BAG6 protein.
靶标信息
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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生物信息学
蛋白别名: BAG 6; BAG family molecular chaperone regulator 6; BAG-6; BAT 3; BCL2-associated athanogene 6; DAQB-195H10.3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAG6; large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe
基因别名: BAG-6; BAG6; BAT3; D6S52E; G3
UniProt ID: (Human) P46379
Entrez Gene ID: (Human) 7917
分子生物学功能:
chaperone
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway
