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FIGURE: 1 / 1
BAG6 Antibody (PA5-96033) in WB
Western blot analysis of BAG6 in extracts of various cell lines. Samples were incubated with BAG6 Polyclonal antibody (Product # PA5-96033) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 90s.
Product Details
PA5-96033
产品规格
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
分类
Polyclonal
类型
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human BAG6.
Conjugate
Unconjugated
形式
Liquid
浓度
0.22 mg/mL
纯化类型
Affinity Chromatography
保存液
PBS, pH 7.3, with 50% glycerol
内含物
0.02% sodium azide
保存条件
-20° C, Avoid Freeze/Thaw Cycles
RRID
AB_2807835
Product Specific Information
Immunogen sequence: MEPNDSTSTA VEEPDSLEVL VKTLDSQTRT FIVGAQMNVK EFKEHIAASV SIPSEKQRLI YQGRVLQDDK KLQEYNVGGK VIHLVERAPP QTHLPSGASS GTGSASATHG GGSPPGTRGP GASVHDRNAN SYVMVGTFNL PSDGSAVDVH INMEQAPIQS EPRVRLVMAQ HMIRDIQTLL SRMECRGGPQ PQHSQPPPQP; Positive Samples: 293T, HeLa, Mouse testis, Rat testis; Cellular Location: Cytoplasm, Nucleus, cytosol
Target Information
This gene was first characterized as part of a cluster of genes located within the human major histocompatibility complex class III region. This gene encodes a nuclear protein that is cleaved by caspase 3 and is implicated in the control of apoptosis. In addition, the protein forms a complex with E1A binding protein p300 and is required for the acetylation of p53 in response to DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
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Bioinformatics
Protein Aliases: BAG 6; BAG family molecular chaperone regulator 6; BAG-6; BAT 3; BCL2-associated athanogene 6; DAQB-195H10.3; HLA-B associated transcript 3; HLA-B associated transcript-3; HLA-B-associated transcript 3; Large proline-rich protein BAG6; large proline-rich protein BAT3; Protein G3; Protein Scythe; scythe
Gene Aliases: 2410045D21Rik; AA408914; BAG-6; BAG6; BAT3; D17H6S52E; D6S52E; G3; Scythe
UniProt ID: (Human) P46379, (Rat) Q6MG49, (Mouse) Q9Z1R2
Entrez Gene ID: (Human) 7917, (Rat) 94342, (Mouse) 224727
Molecular Function:
chaperone
kidney development
immune system process
ubiquitin-dependent protein catabolic process
transport
synaptonemal complex assembly
spermatogenesis
brain development
embryo development
covalent chromatin modification
internal peptidyl-lysine acetylation
cell differentiation
lung development
negative regulation of proteasomal ubiquitin-dependent protein catabolic process
regulation of cell proliferation
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of apoptotic process
negative regulation of proteolysis
protein stabilization
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
tail-anchored membrane protein insertion into ER membrane
positive regulation of ERAD pathway
maintenance of unfolded protein involved in ERAD pathway
protein localization to cytosolic proteasome complex involved in ERAD pathway
chromatin modification
regulation of apoptotic process
antigen processing and presentation of peptide antigen via MHC class I
apoptotic process
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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