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| 应用 | 建议稀释比 | 已发表文章 |
|---|---|---|
免疫印迹 (WB) |
0.1-0.5 µg/mL | - |
| 产品规格 | |
|---|---|
种属反应 |
Human, Mouse, Rat |
宿主/亚型 |
Rabbit / IgG |
分类 |
Polyclonal |
类型 |
Antibody |
抗原 |
E. coli-derived human BAP1 recombinant protein (Position: M1-E278). |
偶联物 |
Unconjugated |
形式 |
Lyophilized |
浓度 |
500 µg/mL |
纯化类型 |
Antigen affinity chromatography |
保存液 |
PBS with 4mg trehalose |
内含物 |
0.05mg sodium azide |
保存条件 |
-20°C |
RRID |
AB_2745972 |
Add 0.2 mL of distilled water, will yield a concentration of 500 µg/mL.
BRCA1-associated protein-1, or BAP1, interacts with the RING finger domain of BRCA1. The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin. In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals. BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns. BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth. Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4. 8-kb transcript expressed exclusively in testis. Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling. The BAP1 gene has been mapped to 3p21. 3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas. Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines. It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.
仅用于科研。不用于诊断过程。未经明确授权不得转售。
蛋白别名: Brca1 associated protein 1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; DKFZp686N04275; FLJ35406; FLJ37180; Ubiquitin C-terminal hydrolase X4; Ubiquitin carboxyl-terminal hydrolase BAP1; UCH-X4
基因别名: 2300006C11Rik; AA989761; AW553466; BAP1; HUCEP-13; hucep-6; KIAA0272; mKIAA0272; uch-x4; UCHL2
UniProt ID: (Human) Q92560, (Rat) D3ZHS6, (Mouse) Q99PU7
Entrez Gene ID: (Human) 8314, (Rat) 306257, (Mouse) 104416
分子生物学功能:
cysteine protease
